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Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
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Sarcomas of the Breast.
Mallory A Duncan1, Meeghan A Lautner2
1Department of General Surgery, UT Health San Antonio, 7703 Floyd Curl Drive, Mail Code 7737, San Antonio, TX 78229, USA.
The Surgical Clinics of North America
|July 15, 2018
Summary
Breast sarcomas are rare cancers distinct from carcinomas, requiring specialized diagnosis and treatment. Despite advances, these rare breast tumors have high recurrence rates and a poor prognosis.
Area of Science:
- Oncology
- Surgical Pathology
- Radiology
Background:
- Breast sarcoma is an exceptionally rare malignancy, distinct from common epithelial breast carcinomas.
- Its unique characteristics necessitate different approaches to staging and treatment protocols.
Purpose of the Study:
- To summarize the diagnostic and therapeutic strategies for breast sarcoma.
- To highlight the differences in management compared to epithelial breast carcinomas.
Main Methods:
- Diagnostic workup involves breast imaging and core biopsy, similar to epithelial breast carcinoma.
- Surgical management options include breast-conserving surgery (wide local excision) or mastectomy.
- Radiation-associated angiosarcomas may require mastectomy with extensive skin excision.
Main Results:
- Breast sarcomas spread hematogenously, thus lymph node evaluation is not part of staging or treatment.
- Local recurrence rates for breast sarcoma are notably high.
- The overall prognosis for breast sarcoma remains poor, even with advancements in epithelial breast carcinoma treatment.
Conclusions:
- Breast sarcoma management requires a tailored approach due to its rarity and distinct biological behavior.
- Effective treatment strategies are limited, and prognosis is generally unfavorable compared to epithelial breast cancers.
