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Targeting the integrin interactome in human disease.
Miguel Vicente-Manzanares1, Francisco Sánchez-Madrid2
1Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer, CIC-IBMCC (CSIC-Universidad de Salamanca), 37007 Salamanca, Spain.
Current Opinion in Cell Biology
|July 15, 2018
Summary
Targeting integrins successfully treats inflammatory diseases by modulating cell adhesion. However, cancer treatment targeting integrins has shown limited success due to cancer cell adaptability.
Area of Science:
- Cellular Biology
- Immunology
- Oncology
Background:
- Integrins are key cell adhesion receptors mediating cell-matrix and cell-cell interactions.
- Microenvironment signals fine-tune integrin function and interactions with other proteins.
- Integrins play critical roles in inflammatory diseases and cancer pathogenesis.
Purpose of the Study:
- To review the therapeutic efficacy of targeting integrins in inflammatory diseases versus cancer.
- To elucidate the reasons behind the differential success of integrin-targeted therapies.
Main Methods:
- Review of clinical trial data and scientific literature on integrin-targeted therapies.
- Analysis of integrin biology in the context of inflammation and cancer progression.
Main Results:
- Integrin-targeting agents have proven effective in managing autoimmune and inflammatory conditions.
- Therapeutic strategies targeting integrins show limited efficacy in treating various cancers.
- Cancer cell plasticity and adaptability contribute to the failure of integrin-targeted anti-cancer therapies.
Conclusions:
- Integrin targeting is a validated strategy for controlling inflammatory diseases.
- The clinical success of integrin inhibition in cancer is hampered by tumor cell adaptability.
- Further research is needed to overcome resistance mechanisms for effective integrin-based cancer therapy.
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