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Chemokines in pregnant women with sickle cell disease

Manuela Freire Hazin-Costa1, Aderson da Silva Aráujo2, Glaucia Lins Guerra3

  • 1Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, 50.070-550 Recife, Pernambuco, Brazil; Fundação de Hematologia e Hemoterapia de Pernambuco HEMOPE, Rua Joaquim Nabuco, 171, Graças, 52.011-000 Recife, Pernambuco, Brazil; Universidade Federal de Pernambuco (UFPE), Av. Prof. Moraes Rego, 1235, Cidade Universitária, 50.670-90 Recife, Pernambuco, Brazil.

Cytokine
|July 15, 2018
PubMed

Pregnancy in sickle cell disease is a problem due to the adverse outcomes related to the disease. Research into the role of chemokines in sickle cell disease is available, but studies investigating the disease in pregnancy are scarce. Our data show the chemokine profiles of pregnant women with sickle cell disease compared with control groups. There were no differences in MCP-1 level among the groups, but IL-8 and MIG were likely related with disease activity. In addition, levels of IP-10 were higher in pregnant women with sickle cell disease and, interestingly, RANTES levels were higher in normal pregnancy when compared to pregnancy in sickle cell disease. More studies should be encouraged to fully elucidate chemokine activity during pregnancy in sickle cell disease.

Keywords:
ChemokinesPregnancySickle cell disease

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