Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcription Factors02:16

Transcription Factors

82.8K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.8K
Factors Affecting Solubility04:01

Factors Affecting Solubility

37.2K
Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.2K
Transcription Elongation Factors02:35

Transcription Elongation Factors

14.0K
Transcription elongation is a dynamic process that alters depending upon the sequence heterogeneity of the DNA being transcribed. Hence, it is not surprising that the elongation complex's composition also varies along the way while transcribing a gene.
The transcription elongation is regulated via pausing of RNA polymerase on several occasions during transcription. In bacteria, these halts are necessary because the transcription of DNA into mRNA is coupled to the translation of that mRNA...
14.0K
Factors Affecting Drug Distribution: Miscellaneous Factors01:19

Factors Affecting Drug Distribution: Miscellaneous Factors

1.0K
Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
1.0K
Electrolytes: van't Hoff Factor03:08

Electrolytes: van't Hoff Factor

37.0K
Colligative Properties of Electrolytes
The colligative properties of a solution depend only on the number, not on the identity, of solute species dissolved. The concentration terms in the equations for various colligative properties (freezing point depression, boiling point elevation, osmotic pressure) pertain to all solute species present in the solution. Nonelectrolytes dissolve physically without dissociation or any other accompanying process. Each molecule that dissolves yields one...
37.0K
Factors Affecting Protein-Drug Binding: Drug-Related Factors01:18

Factors Affecting Protein-Drug Binding: Drug-Related Factors

487
Drug binding to proteins is a complex phenomenon influenced by various drug-related factors, each playing a significant role in the interaction between drugs and proteins within the body.
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
487

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Risk factors and prognostic value of lymph node metastasis in patients undergoing curative resection for intrahepatic cholangiocarcinoma].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2026
Same author

TQB2440 compared with reference pertuzumab for HER2-positive, ER/PgR-negative, early or locally advanced breast cancer: a multicenter, randomized, double-blind, parallel-controlled, phase III equivalence trial.

ESMO open·2025
Same author

[Intervention effect analysis of TPMT and NUDT15 genotyping on the tolerability of azathioprine or 6-mercaptopurine therapy in pediatric inflammatory bowel disease].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2025
Same author

[Phase Ⅲ, multicenter, randomized comparative study of LY01005 and Zoladex<sup>®</sup> for patients with premenopausal breast cancer].

Zhonghua zhong liu za zhi [Chinese journal of oncology]·2025
Same author

Correction to: RhoA/ROCK/PTEN signaling is involved in AT-101-mediated apoptosis in human leukemia cells in vitro and in vivo.

Cell death & disease·2025
Same author

Addressing the pathophysiology of venous thrombosis and chronic kidney disease in sickle cell trait using a mouse model.

Blood advances·2025

Related Experiment Video

Updated: Feb 7, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

10.2K

Factor XI promotes hemostasis in factor IX-deficient mice.

B M Mohammed1,2, Q Cheng1, A Matafonov1

  • 1Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.

Journal of Thrombosis and Haemostasis : JTH
|July 15, 2018
PubMed
Summary

Factor XI (FXI) may influence Factor IX (FIX) deficiency (hemophilia B). In mice, FXI infusion improved hemostasis in FIX-deficient models, suggesting FXI impacts bleeding independent of FIX.

Keywords:
bleedingfactor IXfactor XIhemostasissaphenous vein

More Related Videos

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

8.9K
Generation of Plasmid Vectors Expressing FLAG-tagged Proteins Under the Regulation of Human Elongation Factor-1&#945; Promoter Using Gibson Assembly
10:18

Generation of Plasmid Vectors Expressing FLAG-tagged Proteins Under the Regulation of Human Elongation Factor-1α Promoter Using Gibson Assembly

Published on: February 9, 2015

37.9K

Related Experiment Videos

Last Updated: Feb 7, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
09:04

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors

Published on: March 15, 2016

10.2K
Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome

Published on: June 15, 2016

8.9K
Generation of Plasmid Vectors Expressing FLAG-tagged Proteins Under the Regulation of Human Elongation Factor-1&#945; Promoter Using Gibson Assembly
10:18

Generation of Plasmid Vectors Expressing FLAG-tagged Proteins Under the Regulation of Human Elongation Factor-1α Promoter Using Gibson Assembly

Published on: February 9, 2015

37.9K

Area of Science:

  • Coagulation cascade research
  • Hemostasis and thrombosis
  • Hematology

Background:

  • Human Factor XI (FXI) deficiency is linked to bleeding disorders.
  • FXI-deficient mice previously showed no hemostatic defect, but recent studies suggest a moderate defect.
  • Hemophilia B is caused by Factor IX (FIX) deficiency.

Purpose of the Study:

  • To investigate the role of FXI in bleeding.
  • To examine FXI's effect in mice with normal FIX levels and in a murine model of hemophilia B (FIX-deficient mice).

Main Methods:

  • Utilized a saphenous vein bleeding (SVB) model in wild-type, FIX-deficient (F9-), and FXI-deficient (F11-/-) mice.
  • Manipulated FXI levels in F11-/- mice via infusion or overexpression.
  • Assessed hemostasis in F9- mice after FXI manipulation.

Main Results:

  • FIX-deficient mice exhibited a significant bleeding defect in the SVB model.
  • FXI-deficient mice showed no difference in hemostasis compared to wild-type mice.
  • FXI infusion or overexpression in FIX-deficient mice improved hemostasis, even with a FIX-binding site-deficient FXI variant.

Conclusions:

  • FXI does not appear to cause a hemostatic defect in mice lacking it.
  • Elevated FXI levels enhance hemostasis in FIX-deficient mice.
  • FXI may improve hemostasis in hemophilia B through FIX-independent mechanisms.