Therapeutic landscape in mutational triple negative breast cancer

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Yaqin Shi1, Juan Jin1, Wenfei Ji2

  • 1Department of Medical Oncology, Jinling Hospital, Medical School of Nanjing University, Nanjing, 210002, China.

Molecular Cancer
|July 16, 2018
PubMed

Insights

Triple negative breast cancer (TNBC) exhibits unique genomic alterations. Understanding these mutations, including germline and somatic, offers new avenues for targeted therapies and improved treatment strategies.

Area of Science:

  • Oncology
  • Genomics
  • Cancer Research

Background:

  • Triple negative breast cancer (TNBC) is an aggressive subtype with poor prognosis.
  • TNBC presents a distinct genomic landscape compared to other breast cancer types.
  • While BRCA1/2 germline mutations are clinically relevant, other hereditary cancer predisposition genes in TNBC remain understudied.

Purpose of the Study:

  • To review the germline and somatic mutation profiles specific to TNBC.
  • To discuss the clinical utility of genomic alterations in TNBC.
  • To explore current and emerging therapeutic strategies targeting TNBC mutations.

Main Methods:

  • Comprehensive review of existing literature on TNBC genomics.
  • Analysis of germline and somatic mutation data in TNBC.
  • Synthesis of information on targeted therapies for TNBC.

Main Results:

  • TNBC is characterized by a unique mutational portrait, differing significantly from other breast cancers.
  • Recurrent mutations in TP53 and PI3KCA are observed, alongside numerous rare mutations.
  • Genomic alterations collectively drive TNBC progression.

Conclusions:

  • The heterogeneity of TNBC necessitates a deep understanding of its genomic alterations.
  • Clinical interpretation of TNBC genomic data is crucial for developing tailored therapeutics.
  • Targeting specific mutant proteins and pathways holds promise for advancing TNBC treatment.
Keywords:
GermlineMutationSomaticTNBCTherapeutic

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