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Updated: Feb 7, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
[Proper oral health can protect from developing gingival hyperplasia induced by calcium channel blockers]
Ágnes Bán1, Erika Pintér2, József Kun2
1Klinikai Központ, Fogászati és Szájsebészeti Klinika, Parodontológiai Osztály, Pécsi Tudományegyetem, Fogorvos-tudományi Kar Pécs.
Insights
Calcium channel blockers can cause gingival hyperplasia, a gum overgrowth condition linked to poor oral hygiene and plaque. Maintaining good dental care can prevent this side effect, even during hypertension treatment.
Area of Science:
- Cardiology
- Periodontology
- Pharmacology
Background:
- Cardiovascular diseases, including hypertension, are prevalent, affecting 40% of Hungarian adults.
- Calcium channel blockers (CCBs) are common hypertension treatments, with gingival hyperplasia as a known side effect.
- Gingival hyperplasia induced by CCBs is influenced by dental status and plaque accumulation.
Purpose of the Study:
- To highlight the correlation between CCB-induced gingival hyperplasia, dental health, and plaque levels.
- To emphasize the impact of gingival hyperplasia on oral hygiene and its potential to exacerbate cardiovascular risks.
- To advocate for improved interdisciplinary collaboration between internists and dentists for patient oral health.
Main Methods:
- Observational analysis of patients undergoing calcium channel blocker therapy.
- Assessment of dental status and plaque quantity in relation to gingival hyperplasia.
- Literature review on the mechanisms of CCB-induced gingival overgrowth.
Main Results:
- CCB-induced gingival hyperplasia is closely associated with poor dental hygiene and increased plaque.
- Established gingival hyperplasia complicates oral hygiene, promoting bacterial proliferation and potential cardiovascular disease risk.
- Effective oral hygiene and professional dental care can maintain healthy gingival states during CCB therapy.
Conclusions:
- Gingival hyperplasia management requires addressing dental status and plaque control.
- Preventive oral care is crucial for patients on CCBs to mitigate hyperplasia and associated risks.
- Enhanced collaboration between physicians and dentists is essential for comprehensive patient care.
Abstract:
Cardiovascular diseases including hypertension affect 40% of the adult population in Hungary. Calcium channel blockers are frequently prescribed for the treatment of hypertension either in monotherapy or in fixed-combination therapy. Their main effect is vasodilatation with gingival hyperplasia as a side effect. Our aim is to draw our colleagues' attention to the practical importance of the fact that calcium channel blocker-induced gingival hyperplasia correlates closely with the dental status and the quantity of plaque on the surface of teeth and dental implants. Once established, gingival hyperplasia makes it more difficult for the patient to maintain individual tooth cleaning and increases plaque formation. Thus proliferation of Gram-negative bacteria is enabled in the plaque which promotes gingival overgrowth and can pose a risk factor for further cardiovascular diseases. If proper individual oral hygiene and professional interventions are carried out, healthy and hyperplasia-free gingival state can be sustained in the long term in most cases, even with calcium channel blocker therapy. In order to protect patients' oral health, a closer cooperation of internists and dentists would be desirable. Orv Hetil. 2018; 159(29): 1183-1187.
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