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Studying the Stoichiometry of Epidermal Growth Factor Receptor in Intact Cells using Correlative Microscopy
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Correlation of E-cadherin gene polymorphisms and epidermal growth factor receptor mutation in lung adenocarcinoma

Chun-Yao Huang1,2, Ming-Ju Hsieh1,3,4, Tu-Chen Liu1,5

  • 1Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan.

International Journal of Medical Sciences
|July 17, 2018
PubMed

Insights

Genetic variants in the E-cadherin gene (CDH1) show a significant inverse association with epidermal growth factor receptor (EGFR) mutations in female lung adenocarcinoma patients. These CDH1 variants may influence disease development.

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • Epithelial-mesenchymal transition (EMT) is linked to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) efficacy in non-small cell lung cancer (NSCLC).
  • The E-cadherin gene (CDH1) plays a role in cell adhesion and is implicated in cancer progression.
  • Understanding the interplay between CDH1 genetic variants and EGFR mutations is crucial for lung adenocarcinoma treatment.

Purpose of the Study:

  • To investigate the association between CDH1 genetic variants (rs16260 and rs9929218) and TK-domain mutations of EGFR.
  • To explore the relationship between CDH1 variants, EGFR mutations, and clinicopathologic characteristics in lung adenocarcinoma patients.
  • To determine if CDH1 variants influence the development of lung adenocarcinoma, particularly in relation to EGFR mutations.

Main Methods:

  • A cohort of 280 lung adenocarcinoma patients was analyzed.
  • CDH1 genetic variants (rs16260 and rs9929218) were genotyped using real-time polymerase chain reaction (PCR).
  • Statistical analysis was performed to assess associations between genotypes, EGFR mutations, and clinicopathologic features.

Main Results:

  • CDH1 rs16260 genotypes (CA and CA + AA) were significantly inversely associated with EGFR mutation type in female patients.
  • These CDH1 variants showed a reverse association with specific EGFR hotspot mutations (L858R and exon 19 deletion) in females.
  • The CDH1 rs16260 CA + AA genotype was significantly inversely associated with tumor size in lung adenocarcinoma patients.

Conclusions:

  • CDH1 genetic variants are significantly inversely associated with EGFR tyrosine kinase mutations, particularly in female lung adenocarcinoma patients.
  • These findings suggest that CDH1 variants may play a role in the pathological development of lung adenocarcinoma.
  • Further research is warranted to elucidate the precise mechanisms by which CDH1 variants influence lung adenocarcinoma and EGFR mutation status.
Keywords:
AdenocarcinomaCDH1 geneE-cadherinEpidermal growth factor receptorGenetic variantsPolymorphism

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