Single Bout Exercise in Children with Juvenile Idiopathic Arthritis: Impact on Inflammatory Markers
Emmanuelle Rochette1,2,3,4, Duché Pascale3,4, Christophe Hourdé5
1Pédiatrie Générale Multidisciplinaire, Hôpital Estaing, CHU Clermont-Ferrand, 63000 Clermont-Ferrand, France.
Insights
A single exercise session in children with juvenile idiopathic arthritis (JIA) caused temporary pain and increased plasma calprotectin, but did not affect IL-6 levels. Calprotectin returned to normal within three hours.
Area of Science:
- Pediatric Rheumatology
- Exercise Immunology
- Inflammatory Diseases
Background:
- Juvenile idiopathic arthritis (JIA) involves a deregulated immune system.
- The impact of physical activity on the immune system in JIA is not fully understood.
Purpose of the Study:
- To measure the impact of a single exercise bout on plasma inflammatory markers and the hypothalamic-pituitary-adrenal axis in children with JIA.
- To assess changes in calprotectin, IL-6, sIL-6R, sgp130, cortisol, and ACTH following exercise.
Main Methods:
- Twelve children with JIA participated in a controlled study.
- Participants underwent a non-exercise control day and a day with a 20-minute exercise bout.
- Plasma samples were collected at various time points to measure inflammatory markers and hormone levels.
Main Results:
- A transient, twofold increase in self-reported pain was observed post-exercise.
- Plasma calprotectin showed a 1.7-fold increase (p < 0.001) after exercise.
- Levels of IL-6 and its soluble receptors did not significantly change; calprotectin normalized within 3 hours.
Conclusions:
- Acute exercise in children with JIA can induce mild musculoskeletal pain and transiently elevate plasma calprotectin.
- Exercise did not significantly impact IL-6 levels in this cohort.
- Further research is needed to understand the long-term effects of exercise on JIA.
Objective:
In a context of inflammatory disease such as juvenile idiopathic arthritis (JIA), we do not know what impact physical activity may have on a deregulated immune system. The objective is to measure the impact of a single bout of exercise on plasma inflammatory markers such as calprotectin, IL-6, sIL-6R, sgp130, and the hypothalamic-pituitary-adrenal axis in children with juvenile idiopathic arthritis.
Methods:
Twelve children with JIA performed a nonexercise control day and a consecutive day that included a 20 min exercise bout at 70% of max-HR at 08:30 am. Venous blood samples were taken at 08:30, 08:50, 09:30, 10:30 am, and 12:00 pm to measure plasma concentrations of calprotectin, IL-6, sIL-6R, sgp130, cortisol, and ACTH. Pain was evaluated at 08:30, 08:50 am, and 06:00 pm.
Results:
There was a transient twofold increase in postexercise self-evaluated pain (p = 0.03) that disappeared in the evening. A single bout of exercise resulted in a 1.7-fold increase in plasma calprotectin (p < 0.001) but not IL-6 and its soluble receptors. Calprotectin levels returned to baseline within 3 hours after cessation of exercise.
Conclusion:
Acute exercise in children with JIA induced slightly musculoskeletal leg pain and transient increased plasma calprotectin levels but not IL-6 levels. Trial registration in ClinicalTrials.gov, reference number NCT 02502539, registered on 29 May 2015.
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