Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A model for DNA sequence evolution within transposable element families.

J F Brookfield

    Genetics
    |February 1, 1986
    PubMed
    Summary

    This study introduces a quantitative model to predict the relationship between transposable elements in host populations. The model suggests that transposition leads to distant relationships between elements across genomes in large populations.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correspondence.

    Trends in ecology & evolution·2011
    Same author

    Forced and natural molecular evolution.

    Trends in ecology & evolution·2011
    Same author

    Population bottlenecks.

    Current biology : CB·2001
    Same author

    Selection on Alu sequences?

    Current biology : CB·2001
    Same author

    An investigation of the cause of low variability on the fourth chromosome of Drosophila melanogaster.

    Molecular biology and evolution·2001
    Same author

    Predicting the future.

    Nature·2001

    Area of Science:

    • Genetics
    • Evolutionary Biology
    • Bioinformatics

    Background:

    • Transposable elements (TEs) are mobile DNA sequences that can alter genome structure and function.
    • Understanding the evolutionary dynamics of TEs within host populations is crucial for comprehending genome evolution.
    • Previous models have not fully captured the complex interplay between transposition rates and homogenization processes.

    Purpose of the Study:

    • To develop a quantitative model for predicting the degree of relatedness between copies of transposable element families within finite host populations.
    • To analyze specific scenarios where homogenization is or is not limited by transposition rate.
    • To assess the impact of transposition on the genomic distribution and relatedness of mobile sequences.

    Main Methods:

    • Development of a quantitative population genetics model.
    • Mathematical analysis of special cases, including transposition-rate-limited homogenization.
    • Application and illustration of the model using empirical data from mobile sequences across different species.

    Main Results:

    • The proposed model predicts the expected relatedness between transposable element copies.
    • In large populations, transposition is shown to result in a relatively distant relationship between TEs at different genomic locations.
    • The model's predictions are illustrated with data from various species, demonstrating its applicability.

    Conclusions:

    • Transposable element dynamics in finite populations can be quantitatively modeled.
    • Transposition significantly influences the genomic relatedness of mobile elements, leading to divergence in large populations.
    • The study quantifies potential model inadequacies, paving the way for future refinements.

    Related Experiment Videos