Inhibitory effect of icariin on osteosarcoma cell proliferation via the Wnt/β-catenin signaling pathway

Yuxin Ren1, Fuqiang Zhu1, Zhendong Liu2

  • 1Department of Spinal Surgery, Dezhou People's Hospital, Dezhou, Shandong 253014, P.R. China.

Oncology Letters
|July 17, 2018
PubMed

Insights

Icariin (ICA) effectively inhibits osteosarcoma cell growth and promotes apoptosis. This occurs by downregulating the Wnt/β-catenin pathway, impacting key proteins and reducing tumor-promoting factors like VEGF and MMP-9.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Osteosarcoma is a malignant bone tumor with unclear pathogenesis and chemotherapy resistance.
  • Investigating novel therapeutic agents is crucial for improving osteosarcoma treatment outcomes.

Purpose of the Study:

  • To evaluate the anti-proliferative and pro-apoptotic effects of icariin (ICA) on osteosarcoma cells.
  • To elucidate the role of the Wnt/β-catenin signaling pathway in ICA's mechanism of action.

Main Methods:

  • Osteosarcoma cell line (143B) treated with varying concentrations of ICA.
  • MTT assay for cell viability, flow cytometry for apoptosis analysis.
  • Semi-quantitative PCR, western blot, and ELISA to assess protein and gene expression (Wnt/β-catenin pathway, VEGF, MMP-9).

Main Results:

  • ICA (5 µM) significantly inhibited 143B cell proliferation and increased apoptosis.
  • ICA treatment downregulated key Wnt/β-catenin pathway proteins (p-GSK3β, β-catenin, c-Myc, cyclin D1) and upregulated caspase-3.
  • Expression of vascular endothelial growth factor (VEGF) and MMP-9 was significantly decreased.

Conclusions:

  • Icariin demonstrates significant anti-cancer properties against osteosarcoma cells.
  • ICA exerts its effects by inhibiting the Wnt/β-catenin signaling pathway, leading to reduced proliferation and enhanced apoptosis.
  • ICA represents a potential therapeutic candidate for osteosarcoma treatment.

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