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Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?
Jun Zhu1, Conrad W Merkle1, Marcel T Bernucci1
1Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA.
Applied Sciences (Basel, Switzerland)
|July 17, 2018
Summary
Optical Coherence Tomography Angiography (OCTA) is mainly a visualization tool. This study explores making OCTA a quantitative tool for microvascular hemodynamics to better detect diseases.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Medical Imaging
Background:
- Optical Coherence Tomography Angiography (OCTA) visualizes blood vessels using red blood cell motion.
- Current OCTA applications are primarily qualitative, limiting disease detection.
- Quantitative hemodynamic data could improve early disease diagnosis.
Purpose of the Study:
- To broaden the view of OCTA in microvascular hemodynamics.
- To assess challenges and opportunities in advancing OCTA.
- To transition OCTA from a visualization to a quantitative tool.
Main Methods:
- Analysis of OCTA protocols and algorithms.
- Focus on microvascular hemodynamics and light scattering.
- Consideration of capillary vs. larger vessel imaging challenges.
Main Results:
- OCTA relies on red blood cell motion and scattering for imaging.
- Quantitative hemodynamic information is crucial for disease mechanism delineation.
- Challenges exist in applying OCTA to capillaries.
Conclusions:
- OCTA is currently limited as a visualization tool.
- Advancing OCTA requires addressing microvascular complexities.
- Developing quantitative OCTA capabilities is essential for improved disease detection.
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