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Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children

Asma Deeb1, Salima Attia1, Samia Mahmoud2

  • 1Pediatric Endocrinology Department, Mafraq Hospital, P.O. Box 2951, Abu Dhabi, UAE.

Journal of Obesity
|July 17, 2018
PubMed

Insights

Dyslipidemia and fatty liver disease (FLD) are common in obese children. Waist circumference (WC) is a useful screening tool for these conditions in pediatric obesity.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Disorders
  • Public Health

Background:

  • Childhood obesity is a growing global health concern, particularly in the Gulf region.
  • Obesity is linked to significant comorbidities, including dyslipidemia and liver disease.
  • There is a need to understand the prevalence of these conditions in overweight and obese children.

Purpose of the Study:

  • To determine the prevalence of dyslipidemia and fatty liver disease (FLD) in overweight and obese children.
  • To analyze the association between anthropometric measures and these conditions.
  • To identify effective screening tools for early detection.

Main Methods:

  • A descriptive, cross-sectional study involving children referred for obesity.
  • Measurement of Body Mass Index (BMI) percentiles and standardized waist circumference (WC).
  • Assessment of lipid profiles, liver transaminases, and liver ultrasound (US) for diagnosis.

Main Results:

  • The study included 216 children with a mean age of 10.58 years.
  • 55.3% of participants had dyslipidemia, with varying levels of cholesterol, triglycerides, LDL, and HDL.
  • Fatty liver disease (FLD) was diagnosed in 43 children, with 84% showing elevated liver transaminases. Waist circumference (WC) showed a significant association with both dyslipidemia (P=0.04) and FLD (P=0.003).

Conclusions:

  • Dyslipidemia is highly prevalent in overweight and obese children.
  • Fatty liver disease (FLD) is common in this population, especially those with elevated liver enzymes.
  • Waist circumference (WC) serves as a practical and effective tool for screening dyslipidemia and FLD in pediatric obesity.
Abstract

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