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The effect of nitro-oleic versus losartan in diabetic nephropathy: modulation of parathyroid hormone-related protein

A S Mohammed1, N B Sadek1, M A Eshra1

  • 1Department of Physiology, Faculty of Medicine, Cairo University, Egypt.

Folia Morphologica
|July 17, 2018
PubMed
Abstract

Insights

Losartan and nitro-oleic acid show potential in preventing and treating diabetic kidney disease by reducing parathyroid hormone-related protein (PTHrP) and improving kidney function and structure.

Area of Science:

  • Nephrology
  • Endocrinology
  • Pharmacology

Background:

  • Parathyroid hormone-related protein (PTHrP) is implicated in angiotensin II (AngII)-induced renal injury.
  • Diabetic nephropathy (DN) is a significant complication of diabetes mellitus.

Purpose of the Study:

  • To compare the preventive and therapeutic effects of AngII antagonists, losartan and nitro-oleic acid (NO2-OA), on diabetic nephropathy in rats.
  • To evaluate the impact of these agents on PTHrP modulation and kidney parameters.

Main Methods:

  • Adult male Sprague Dawley rats were divided into control, DN, and treatment groups (pre- and post-DN with losartan or NO2-OA).
  • Evaluated systolic blood pressure, glucose, GFR, urea, albuminuria, AngII, and renal PTHrP gene expression.
  • Histopathological analysis included Masson's trichrome, PAS staining, and scoring of tubular and glomerular damage.

Main Results:

  • Prophylactic losartan and NO2-OA improved blood pressure, glucose control, kidney function, and reduced AngII and PTHrP levels.
  • Losartan and NO2-OA treatments generally improved kidney parameters, though post-DN NO2-OA had less effect on kidney function.
  • Strong correlations were found between PTHrP and SBP, glucose, AngII, and kidney function. Histopathology showed improvements, particularly with prophylactic losartan.

Conclusions:

  • Both pre- and post-DN administration of losartan and NO2-OA may protect against and help regress diabetic nephropathy.
  • These effects are potentially mediated by the reduction of PTHrP overexpression.
Keywords:
angiotensin IIdiabetic nephropathylosartannitro-oleic acidparathyroid hormone related protein

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