Related Experiment Videos
Pathogenesis of buffalo-pox virus in buffalo calves
International Journal of Zoonoses
|June 1, 1985
Summary
Buffalo-pox virus (BP4 strain) causes a bimodal fever and distinct skin lesions in calves. The virus spreads from the inoculation site to lymph nodes, bloodstream, and organs within days.
Area of Science:
- Veterinary Virology
- Pathogen Biology
Background:
- Buffalo-pox virus (BP4 strain) is a significant pathogen affecting livestock.
- Understanding its pathogenesis is crucial for disease control.
Purpose of the Study:
- To elucidate the pathogenesis of buffalo-pox virus (BP4 strain) in buffalo calves.
- To document clinical signs, lesion progression, and viral dissemination.
Main Methods:
- Intradermal inoculation of buffalo calves with buffalo-pox virus (BP4 strain).
- Clinical observation, gross and microscopic examination of tissues.
- Viral detection and quantification in various tissues and blood.
Main Results:
- Bimodal thermal reaction and characteristic skin lesion progression (reseolar, papular, vesicular, pustular, desquamative).
- Rapid viral replication after an eclipse phase, disseminating to lymph nodes, bloodstream (associated with WBCs), and organs (lung, liver, spleen).
- Secondary viremia on day 6, with pathological changes observed in multiple organs, including the gastrointestinal tract.
Conclusions:
- The study details the clinical and pathological progression of buffalo-pox virus infection in calves.
- Viral dissemination occurs systemically, affecting various organs and leading to characteristic clinical manifestations.
- The findings provide insights into the disease course and viral spread, aiding in diagnosis and management strategies.