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Updated: Feb 7, 2026

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Successful termination of sustained transmission of resident MRSA following extensive NICU refurbishment: an

A Semple1, E O'Currain1, D O'Donovan1

  • 1Academic Department of Paediatrics, National University of Ireland, Galway, Ireland.

The Journal of Hospital Infection
|July 17, 2018
PubMed
Abstract

Insights

Refurbishing a neonatal unit successfully stopped the spread of Meticillin-resistant Staphylococcus aureus (MRSA). This intervention reduced MRSA colonization and prevented new infections in infants, improving neonatal intensive care unit safety.

Area of Science:

  • Neonatal intensive care
  • Infectious disease epidemiology
  • Healthcare facility design

Background:

  • Neonatal sepsis is a major cause of infant illness and death globally.
  • Meticillin-resistant Staphylococcus aureus (MRSA) is a significant pathogen in neonatal units.
  • Eradicating endemic MRSA colonization and infection in neonatal settings is challenging.

Purpose of the Study:

  • To evaluate the effect of neonatal unit refurbishment on endemic MRSA.
  • To determine if redesigning a neonatal unit can control MRSA transmission.

Main Methods:

  • Retrospective review of eight years of data (2008-2015) in a 14-cot neonatal unit.
  • Analysis of surveillance, colonization, and infection data pre- and post-refurbishment.
  • Utilized an interrupted time-series design with refurbishment as the intervention.

Main Results:

  • Sustained transmission of endemic MRSA strains was observed prior to refurbishment.
  • Complete unit refurbishment successfully terminated sustained MRSA transmission.
  • Post-refurbishment, MRSA colonization decreased, and no new infant infections occurred.

Conclusions:

  • Neonatal unit redesign and refurbishment can effectively halt endemic MRSA transmission.
  • Physical environment changes are crucial for controlling persistent hospital-acquired infections.
  • Successful eradication of endemic MRSA was achieved through structural unit improvements.
Keywords:
Infection controlMeticillin-resistantNeonatal intensive care unitNeonateSepsisStaphylococcus aureus

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