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Study on the dissolution improvement of albendazole using reconstitutable dry nanosuspension formulation
Viktor Fülöp1, Géza Jakab1, Tamás Bozó2
1Semmelweis University, Department of Pharmaceutics, Hőgyes Endre Street 7, Budapest H-1092, Hungary.
Summary
This study enhanced albendazole solubility and dissolution using surfactant-assisted media milling and solidification. The resulting dry nanosuspension improved drug delivery in biorelevant media.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Drug Delivery
Background:
- Poor water solubility of albendazole limits its bioavailability.
- Developing effective solid dosage forms for poorly soluble drugs is crucial.
Purpose of the Study:
- To enhance the solubility and dissolution rate of albendazole.
- To create a stable, solid nanosuspension for improved drug applicability.
Main Methods:
- Surfactant-assisted media milling to create albendazole nanosuspension.
- Solidification using microcrystalline cellulose and tray drying.
- Characterization using dynamic light scattering, thermodynamic solubility studies, AFM, and SEM.
- Dissolution studies in biorelevant Artificial Rumen Fluid (ARF) and standard dissolution media.
Main Results:
- Nanosized albendazole crystals (around 200 nm) were successfully reconstituted.
- Significant increase in thermodynamic solubility: 2.98-fold in ARF (pH 6.50) and 2.33-fold in dissolution media (pH 6.80).
- Enhanced dissolution rates observed across tested pH values.
- AFM and SEM confirmed albendazole incorporation into the microcrystalline cellulose structure, not surface deposition.
Conclusions:
- Surfactant-assisted media milling and solidification effectively produced a stable albendazole nanosuspension.
- The developed solid nanosuspension significantly improves albendazole solubility and dissolution.
- This approach holds promise for enhancing the oral bioavailability of poorly water-soluble drugs like albendazole.
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