Related Experiment Video
Updated: Feb 7, 2026

Mouse Oocyte Microinjection, Maturation and Ploidy Assessment
Published on: July 23, 2011
The role of propofol on mouse oocyte meiotic maturation and early embryo development
Xia-Guang Duan1, Zai-Qing Huang2, Chun-Guang Hao2
12The Key Laboratory of National Education Ministry for Mammalian Reproductive Biology and Biotechnology,The Research Center for Laboratory Animal Science,College of Life Science,Inner Mongolia University, Hohhot, Inner Mongolia, People's Republic of China.
Abstract:
SummaryPropofol is a intravenous anaesthetic most commonly used in ultrasound oocyte retrieval. We studied if the use of propofol had an effect on mouse oocyte maturation, pregnancy, childbirth and progeny and investigated the correlation between propofol side effects and reproductive performance in mice. There was no statistical difference in mating, pregnancy, childbirth, litter size, the number of stillbirths and survival between each group (P>0.05). Propofol also had no effect on polar body extrusion in oocyte maturation as well as on pronucleus formation and, subsequently, early embryo development (P>0.05). An increased concentration of propofol had no effect on this result, although propofol at more than 0.01 mg/ml reduced polar body extrusion. Different concentrations of propofol had no effect on oocyte culture in vitro, pronucleus formation and early embryo development.
More Related Videos
Related Concept Videos
Development of the Sexual Organs in the Embryo and Fetus
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
Seed Structure and Early Development of the Sporophyte
Maturation of Endosomes
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
Bacterial Protein Maturation
Fruit Development, Structure, and Function
Role of Septins
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...

