Related Experiment Video

Updated: Feb 7, 2026

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

6.4K

Physiological responses to leptin levels in lipodystrophy: a model for other hypoleptinemias?

Michael Rosenbaum, Rudolph L Leibel

    The Journal of Clinical Investigation
    |July 17, 2018
    PubMed

    More Related Videos

    Measurements of Physiological Stress Responses in C. Elegans10:36

    Measurements of Physiological Stress Responses in C. Elegans

    Published on: May 21, 2020

    15.0K
    Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses07:56

    Isolation of Intrapulmonary Artery and Smooth Muscle Cells to Investigate Vascular Responses

    Published on: June 8, 2022

    4.8K

    Related Concept Videos

    Clearance Models: Physiological Models01:09

    Clearance Models: Physiological Models

    Drug clearance is a critical pharmacokinetic process involving the irreversible removal of drugs from the body through various organs over a specified time period. Physiological models are indispensable in determining organ-specific clearance, defined by the proportion of the drug eliminated per unit of time from the organ's blood volume.
    The organ's clearance rate depends on the blood flow to the organ and the extraction ratio (E). The extraction ratio describes the organ's...
    326
    Model Approaches for Pharmacokinetic Data: Physiological Models01:15

    Model Approaches for Pharmacokinetic Data: Physiological Models

    Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
    279
    Physiological Pharmacokinetic Models: Assumption with Protein Binding01:13

    Physiological Pharmacokinetic Models: Assumption with Protein Binding

    Physiological models with protein binding in pharmacokinetics offer a sophisticated approach to understanding drug disposition. These models consider drug-protein interactions, enabling them to effectively predict drug concentrations in different organs and tissues. This precision aids in accurate drug dosing, providing a significant advantage over conventional models. A key process within these models is equilibration, which ensures that drug concentrations achieve a steady state within the...
    264
    Leveling Effect01:29

    Leveling Effect

    In acid-base chemistry, the leveling effect refers to the limitation imposed by the solvent on the strength of acids and bases in solution. When a base stronger than the solvent's conjugate base is used, it deprotonates the solvent until the base is entirely consumed, making it ineffective against weaker acids. Conversely, an acid stronger than the solvent's conjugate acid protonates the solvent until the acid is depleted, rendering it ineffective against weaker bases. Essentially, the...
    1.4K
    High-Level and Low-Level Awareness01:19

    High-Level and Low-Level Awareness

    Controlled processes in human consciousness represent high-alert mental states where individuals deliberately focus their attention on achieving specific goals. Controlled processes can be seen in situations like mastering new technology, where a person might become so absorbed that they ignore surrounding distractions. Such processes involve selective attention, requiring one to concentrate on particular elements of experience while disregarding others. These are governed by executive...
    784
    Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models00:57

    Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models

    Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
    353