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Acute renal involvement in organophosphate poisoning: histological and immunochemical investigations

Yasemin Kaya1, Orhan Bas2, Hatice Hanci3

  • 1a Department of Internal Medicine, Faculty of Medicine , Ordu University , Ordu , Turkey.

Renal Failure
|July 18, 2018
PubMed
Abstract

Insights

Acute fenthion exposure, an organophosphate pesticide, causes kidney damage in rats. Histopathology revealed tubular degeneration, cell loss, and hemorrhage, indicating potential kidney injury from organophosphate toxicity.

Area of Science:

  • Toxicology
  • Nephrology
  • Histopathology

Background:

  • Organophosphate (OP) compounds are widely used pesticides.
  • Cholinesterase inhibition is a known effect of OPs.
  • Long-term renal effects of partial cholinesterase exposure require further investigation.

Purpose of the Study:

  • To histopathologically investigate the renal effects of acute fenthion toxicity.
  • To determine if fenthion exposure causes kidney damage.

Main Methods:

  • 21 rats were divided into control, sham, and experimental groups.
  • The experimental group received an intraperitoneal injection of fenthion.
  • Kidney tissues were examined histopathologically and biochemically 24 hours post-exposure.

Main Results:

  • Control group showed no renal histopathological findings.
  • Fenthion-exposed rats exhibited tubular epithelial cell disorganization, loss, degeneration, and atrophy.
  • Hemorrhage and apoptosis were observed in the kidneys of fenthion-treated rats, with mild degeneration in the sham group.

Conclusions:

  • Acute fenthion toxicity can cause significant cellular injury to glomerular and tubular kidney structures.
  • Kidney damage may contribute to systemic complaints associated with organophosphate poisoning.
  • Further research is needed to understand the full spectrum of renal effects from OP exposure.
Keywords:
Organophosphatefenthionhistopathological investigationpoisoningrenal injury

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