Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fischer Projections02:18

Fischer Projections

16.6K
Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
16.6K
Newman Projections02:06

Newman Projections

21.2K
Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as...
21.2K
Trial and Error and Algorithm01:12

Trial and Error and Algorithm

425
A problem-solving strategy is a plan of action used to find a solution. Different strategies have distinct action plans. Trial and error involves trying different solutions until one works. For instance, to fix a broken printer, you might check ink levels, ensure the paper tray isn't jammed, and verify the printer's connection to your laptop. This method can be time-consuming but is commonly used. Thomas Edison, for example, used trial and error to find a suitable filament for the light...
425
Coordinates and Map Projections01:29

Coordinates and Map Projections

623
Coordinates and map projections are essential tools in accurately representing the Earth's surface for various applications, ranging from navigation to spatial analysis. The latitude and longitude coordinate system is a universally recognized framework for defining locations. Latitude specifies the distance of a point north or south of the equator, measured in degrees from 0° at the equator to 90° at the poles. Longitude indicates a location's position east or west of the prime meridian,...
623
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

319
Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
319
Lewis Acids and Bases02:33

Lewis Acids and Bases

48.4K
In 1923, G. N. Lewis proposed a generalized definition of acid-base behavior in which acids and bases are identified by their ability to accept or to donate a pair of electrons and form a coordinate covalent bond.
A coordinate covalent bond (or dative bond) occurs when one of the atoms in the bond provides both bonding electrons. For example, a coordinate covalent bond occurs when a water molecule combines with a hydrogen ion to form a hydronium ion. A coordinate covalent bond also results when...
48.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exploring Anti-Aging Literature via <i>ConvexTopics</i> and Large Language Models.

AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science·2026
Same author

Validation of a 2-Gene Blood Test for Kawasaki Disease in Febrile Children.

JAMA network open·2026
Same author

Deep learning for predicting patient drug response by transferring gene-level and cell-level knowledge to tumors.

NPJ precision oncology·2026
Same author

Exploring Anti-Aging Literature via <i>ConvexTopics</i> and Large Language Models.

ArXiv·2026
Same author

Effects of Maternal Tetramethyl Bisphenol F Exposure on Neurodevelopment and Behavior in Mouse Offspring.

International journal of molecular sciences·2026
Same author

Enacted practices and developmental experiences of senior medical student tutors in a structured peer tutoring program.

Korean journal of medical education·2026
Same journal

Research on multi-trait genome association study method based on Shannon information entropy.

BMC bioinformatics·2026
Same journal

A multi-view feature fusion framework with interpretable graph convolution for predicting microbe-drug associations.

BMC bioinformatics·2026
Same journal

Covariance decomposition for distance based species tree estimation.

BMC bioinformatics·2026
Same journal

SNPio: a Python interface for population genomic data processing.

BMC bioinformatics·2026
Same journal

SpaHNR: a spatial domain identification method via sparse attention-based hierarchical node representation and multi-view contrastive learning.

BMC bioinformatics·2026
Same journal

OpenIMC: an open-source platform for analyzing single-cell and spatial proteomics by imaging mass cytometry.

BMC bioinformatics·2026
See all related articles

Related Experiment Video

Updated: Feb 7, 2026

Synthesis of Keratin-based Nanofiber for Biomedical Engineering
14:43

Synthesis of Keratin-based Nanofiber for Biomedical Engineering

Published on: February 7, 2016

16.0K

Discovering themes in biomedical literature using a projection-based algorithm.

Lana Yeganova1, Sun Kim2, Grigory Balasanov2

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, USA. lana.yeganova@nih.gov.

BMC Bioinformatics
|July 18, 2018
PubMed
Summary
This summary is machine-generated.

A new theme-based algorithm analyzes document collections by linking documents and keywords. This method effectively clusters documents and identifies coherent topics, proving scalable for large datasets.

Keywords:
First singular vectorProjection algorithmTheme discovery

More Related Videos

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.6K
Area-based Image Analysis Algorithm for Quantification of Macrophage-fibroblast Cocultures
07:05

Area-based Image Analysis Algorithm for Quantification of Macrophage-fibroblast Cocultures

Published on: February 15, 2022

3.0K

Related Experiment Videos

Last Updated: Feb 7, 2026

Synthesis of Keratin-based Nanofiber for Biomedical Engineering
14:43

Synthesis of Keratin-based Nanofiber for Biomedical Engineering

Published on: February 7, 2016

16.0K
Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
05:47

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

1.6K
Area-based Image Analysis Algorithm for Quantification of Macrophage-fibroblast Cocultures
07:05

Area-based Image Analysis Algorithm for Quantification of Macrophage-fibroblast Cocultures

Published on: February 15, 2022

3.0K

Area of Science:

  • Information Science
  • Computer Science
  • Bioinformatics

Background:

  • Organizing large document collections is crucial for comprehension.
  • Document clustering and topic modeling are common overview approaches.
  • Simultaneous document clustering and keyword finding is an active research area.

Purpose of the Study:

  • To present a novel algorithm for analyzing document collections.
  • To introduce a new vector space mechanism for computing themes.
  • To demonstrate the effectiveness and scalability of the proposed method.

Main Methods:

  • Developed a theme-based algorithm defining themes as dual document-key term representations.
  • Utilized a novel vector space mechanism and a projection algorithm for theme computation.
  • Applied the algorithm to a large collection of PubMed documents on Single Nucleotide Polymorphism.

Main Results:

  • The algorithm iteratively refines document and term representations to detect themes.
  • The projection algorithm converges to the first singular vector under specific conditions.
  • The method demonstrated effectiveness and scalability on a dataset of ~60,000 PubMed documents.

Conclusions:

  • The study offers theoretical and algorithmic contributions to document analysis.
  • The method is feasible for large-scale applications.
  • The proposed system favorably compares with state-of-the-art methods for document clustering and topic term identification.