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Published on: February 11, 2022
Is It Conceivable to Still Perform the Cut and Sew Cox Maze III Procedure in the Current Era?
Fernando A Atik1, Gustavo G Gomes2, Fillipe F Rodrigues1
1Department of Cardiovascular Surgery.
Insights
The Cox maze III procedure for atrial fibrillation is safe when combined with other heart surgeries, showing low mortality and good rhythm outcomes. Increased procedure complexity did not worsen safety, except for a higher need for pacemakers.
Area of Science:
- Cardiology
- Cardiac Surgery
Background:
- Atrial fibrillation is a common arrhythmia often requiring surgical intervention.
- The Cox maze III procedure is a standard surgical treatment for atrial fibrillation.
- Its safety in conjunction with other open-heart procedures needs ongoing evaluation.
Purpose of the Study:
- To assess the safety and efficacy of the Cox maze III procedure when performed with other cardiac surgeries.
- To evaluate the impact of surgical complexity on safety endpoints.
Main Methods:
- A retrospective analysis of 113 adult patients undergoing Cox maze III procedure with other cardiac surgeries between 2008 and 2015.
- Data collected included patient demographics, procedure details, and perioperative outcomes.
- Statistical analysis to correlate the number of associated procedures with morbidity and mortality.
Main Results:
- Hospital mortality was 1.77%, with low rates of re-exploration (0.9%), stroke (1.8%), and acute renal failure (2.6%).
- Sinus rhythm was maintained in 88% at 6 and 12 months, and 85% at 24 months.
- Increased number of associated procedures did not correlate with poorer safety outcomes, except for a higher requirement for permanent pacemakers (18.2% with 3 procedures vs. 4% with 2).
Conclusions:
- The cut and sew Cox maze III procedure is a safe and effective treatment for atrial fibrillation in patients with structural heart disease, even when combined with other complex cardiac surgeries.
- Surgical complexity, indicated by the number of concomitant procedures, did not compromise safety endpoints, with the exception of an increased need for permanent pacemaker implantation.
Abstract:
To determine whether cut and sew Cox maze III procedure is still associated with adequate safety endpoints when performed in conjunction with other open-heart procedures. Between January 2008 and January 2015, 113 consecutive adult patients were submitted to cut and sew Cox maze III procedure in association with other operations for structural heart disease. Mean age was 49 years and 80 (70.8%) were females. Longstanding or persistent atrial fibrillation has occurred in 87.6% and rheumatic heart disease in 80.7%. Valve surgery was performed in 98.2%. The number of associated procedures was correlated with morbidity and hospital mortality. Overall mean cardiopulmonary bypass and aortic cross-clamping times were 129 ± 26 and 105 ± 23 minutes, respectively. Hospital mortality was 1.77%, re-exploration for bleeding 0.9%, cerebrovascular accident 1.8%, and acute renal failure requiring hemodialysis 2.6%. The greater number of associated procedures did not correlate with poorer safety outcomes. Permanent pacemaker was required in 18.2% of those with three associated procedures, as opposed to 4% with two procedures and no requirement with one procedure (P = .01). Frequency of sinus rhythm was 88%, 88%, and 85% at 6, 12, and 24 months, respectively. In a contemporary single-center cohort of predominantly rheumatic patients, the surgical treatment of atrial fibrillation associated with structural heart disease by means of cut and sew Cox maze III procedure is safe, with low morbidity and mortality rates. Surgical complexity, defined by number of associated procedures, did not translate into poorer safety endpoints, except for greater need of permanent pacemaker.
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