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Hippocampus-dependent emergence of spatial sequence coding in retrosplenial cortex.

Dun Mao1, Adam R Neumann2, Jianjun Sun2

  • 1Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada; zjumao@gmail.com bruce.mcnaughton@uleth.ca.

Proceedings of the National Academy of Sciences of the United States of America
|July 18, 2018
PubMed
Summary

The hippocampus is crucial for developing spatial activity in the retrosplenial cortex (RSC), influencing spatial learning and memory. Bilateral hippocampal damage prevents this essential neural activity from emerging in the RSC.

Keywords:
hippocampal indexing theoryhippocampusretrosplenial cortexspatial learningspatial sequence coding

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Spatial Navigation

Background:

  • The retrosplenial cortex (RSC) plays a key role in visuospatial integration and spatial learning.
  • RSC neurons display sequential activity patterns similar to hippocampal place cells, suggesting a shared role in spatial representation.

Purpose of the Study:

  • To investigate the origins and population dynamics of spatial activity in the dysgranular RSC.
  • To determine the role of the hippocampus in the emergence and stability of RSC spatial coding.

Main Methods:

  • Longitudinal cellular calcium imaging of dysgranular RSC neurons in mice.
  • Excitotoxic bilateral and unilateral hippocampal lesions were performed.
  • Tracking the emergence and stability of RSC spatial activity over time.

Main Results:

  • Spatial activity in the RSC is experience-dependent and emerges gradually.
  • RSC spatial codes exhibit dynamic changes across days, mirroring hippocampal activity.
  • Bilateral, but not unilateral, hippocampal lesions significantly impaired the development of RSC spatial activity.

Conclusions:

  • An intact hippocampus is critical for the emergence of spatial activity in the retrosplenial cortex.
  • The hippocampus influences RSC spatial coding, potentially through polysynaptic indirect connections within the neocortex.