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Validation of Heel Stick Microsampling To Optimize Micafungin Doses in Neonates and Young Infants
Cinzia Auriti1, Bianca Maria Goffredo2, Maria Paola Ronchetti3
1Neonatal Intensive Care Unit, Bambino Gesù Children's Hospital, Rome, Italy cinzia.auriti@opbg.net.
Abstract:
Major gaps exist in our knowledge of antimicrobial pharmacokinetics in critically ill neonates and infants that require validated microsampling and bioanalysis methods to support therapeutic drug monitoring. We compared serially collected intravenous (i.v.) and heel stick capillary (HSC)-sampled plasma concentrations of micafungin (8 mg/kg) in eight infants born preterm with systemic candidiasis. The mean (standard deviation) micafungin area under the plasma concentration-time curve to infinity (AUCinf) was 316 (65.0) h · mg/liter based on HSC concentrations that strongly correlated (R2 = 0.92) with i.v. values to support dose adjustment.
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