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The proangiogenic role of polymorphonuclear myeloid-derived suppressor cells in mice infected with Echinococcus

Jianhai Yin1, Yujuan Shen1, Aiping Yu1

  • 1National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Chinese Center for Tropical Diseases Research, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Key Laboratory of Parasite and Vector Biology, Ministry of Health.

Bioscience Trends
|July 18, 2018
PubMed

Insights

Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) promote blood vessel growth (angiogenesis) in mice infected with Echinococcus granulosus. This finding offers insights into echinococcosis pathogenesis and potential therapeutic targets.

Area of Science:

  • Immunology
  • Parasitology
  • Angiogenesis Research

Background:

  • Echinococcus granulosus infection triggers immune responses.
  • Myeloid-derived suppressor cells (MDSCs) modulate immune activity.
  • Angiogenesis plays a role in parasitic infections.

Purpose of the Study:

  • To evaluate the proangiogenic activity of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) in Echinococcus granulosus-infected mice.
  • To investigate the role of PMN-MDSCs in host angiogenesis during infection.
  • To identify specific angiogenic factors involved.

Main Methods:

  • Isolation and in vitro culture of PMN-MDSCs from infected mice.
  • Human umbilical vein endothelial cell (HUVEC) tube-formation assay.
  • Analysis of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) expression.

Main Results:

  • PMN-MDSCs from infected mice significantly promoted HUVEC tube formation.
  • Vascular endothelial growth factor (VEGF) levels were elevated in serum and expressed by PMN-MDSCs.
  • Increased VEGF mRNA and decreased soluble fms-like tyrosine kinase-1 (sFlt-1) were observed in PMN-MDSCs from infected mice.

Conclusions:

  • Host angiogenesis in E. granulosus infection is promoted by PMN-MDSCs.
  • VEGF is a key proangiogenic factor secreted by PMN-MDSCs in this model.
  • Further research is needed to elucidate other angiogenic factors for echinococcosis treatment.
Keywords:
Echinococcus granulosusPolymorphonuclear myeloid-derived suppressor cellsproangiogenicsoluble fms-like tyrosine kinase-1vascular endothelial growth factor

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