Related Experiment Video

Updated: Feb 7, 2026

Robot-Assisted Kidney Transplantation
07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

4.4K

Maintenance of Kidney Metabolic Homeostasis by PPAR Gamma

Patricia Corrales1, Adriana Izquierdo-Lahuerta2, Gema Medina-Gómez3,4

  • 1Área de Bioquímica y Biología Molecular, Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos. Avda. de Atenas s/n. Alcorcón, 28922 Madrid, Spain. patricia.corrales@urjc.es.

International Journal of Molecular Sciences
|July 18, 2018
PubMed

Insights

Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in kidney metabolism, influencing lipid and glucose regulation, mineral control, and blood pressure. Its activation offers reno-protective effects, highlighting its importance in maintaining systemic homeostasis.

Area of Science:

  • Endocrinology
  • Nephrology
  • Molecular Biology

Background:

  • Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors regulating gene transcription.
  • PPARγ, a key subtype, influences lipid metabolism, insulin sensitivity, differentiation, and cancer.
  • PPARγ is expressed in the kidney, impacting renal metabolism and systemic homeostasis.

Purpose of the Study:

  • To review the role of PPARγ in renal metabolism.
  • To highlight PPARγ's involvement in lipid and glucose metabolism, mineral control, and the renin-angiotensin-aldosterone system.
  • To discuss the reno-protective effects of PPARγ agonists.

Main Methods:

  • Literature review of studies on PPARγ in kidney function.
  • Analysis of PPARγ's impact on metabolic pathways within the kidney.
  • Examination of the relationship between PPARγ, the renin-angiotensin-aldosterone system, and blood pressure control.

Main Results:

  • PPARγ modulates kidney lipid and glucose metabolism.
  • PPARγ influences renal mineral handling and systemic blood pressure via the renin-angiotensin-aldosterone system.
  • Synthetic PPARγ agonists demonstrate reno-protective effects in various patient groups.

Conclusions:

  • PPARγ is a significant factor in maintaining kidney function and systemic homeostasis.
  • Targeting PPARγ offers potential therapeutic strategies for kidney diseases.
  • Further research into PPARγ's renal functions is warranted.
Keywords:
PPARγRAASkidneylipidmetabolismnuclear receptors

More Related Videos

The Mouse Isolated Perfused Kidney Technique08:19

The Mouse Isolated Perfused Kidney Technique

Published on: November 17, 2016

23.4K
Maintenance of a Drosophila melanogaster Population Cage08:03

Maintenance of a Drosophila melanogaster Population Cage

Published on: March 15, 2016

14.0K

Related Concept Videos

What is Homeostasis?01:16

What is Homeostasis?

Maintaining homeostasis requires that the body continuously maintain its internal conditions. Each physiological condition has a particular set point, from body temperature to blood pressure to levels of certain nutrients. A set point is the physiological value around which the normal range fluctuates. A normal range is a restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F).
56.7K
pH Homeostasis01:31

pH Homeostasis

Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
19.4K
Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
75.4K
What is Metabolism?00:52

What is Metabolism?

Overview
132.0K
Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
6.0K
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.8K