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Retinopathy of prematurity in the United Kingdom: retreatment rates, visual and structural 1-year outcomes

Gillian Gw Adams1, Catey Bunce1,2, Wen Xing1

  • 1NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of Ophthalmology, 162 City Road, London, EC1V 2PD, UK.

Eye (London, England)
|July 18, 2018
PubMed

Insights

Retreatment rates for retinopathy of prematurity (ROP) were evaluated. Higher retreatment rates were observed after anti-VEGF antibody treatment compared to diode laser for ROP.

Area of Science:

  • Ophthalmology
  • Neonatal care
  • Public health

Background:

  • Retinopathy of prematurity (ROP) is a leading cause of childhood blindness.
  • Effective treatment strategies are crucial for optimizing visual outcomes in affected infants.
  • Understanding long-term outcomes, including retreatment rates and visual acuity, is essential for clinical practice and public health initiatives.

Purpose of the Study:

  • To evaluate retreatment rates in infants treated for ROP.
  • To assess visual and anatomical outcomes at 1-year postnatal age following ROP treatment.
  • To compare outcomes based on initial treatment modality (diode laser vs. anti-VEGF antibody).

Main Methods:

  • A longitudinal national surveillance study was conducted in the United Kingdom.
  • Infants treated for ROP between December 2013 and December 2014 were included.
  • One-year follow-up data on retreatment, visual acuity, refractive error, and sight impairment were collected.

Main Results:

  • Follow-up data were obtained for 168 children (51.4% of the cohort).
  • Retreatment was required in 11.1% of eyes treated initially with diode laser and 35.7% treated with anti-VEGF antibody.
  • Median visual acuity was 0.6 logMAR (best corrected) and 0.4 logMAR (both eyes open). Refractive outcomes showed a trend towards emmetropia/myopia after diode laser.

Conclusions:

  • Retreatment rates for ROP appear higher with initial anti-VEGF antibody treatment than with diode laser.
  • Refractive outcomes are comparable to previous studies, with a tendency towards early emmetropia and myopia following diode laser treatment.
  • These findings provide valuable insights into the long-term efficacy and potential complications of different ROP treatment modalities.
Abstract

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