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Changes in antioxidant status associated with haemodialysis in chronic kidney disease

Adeyemi Ogunleye1, Akinwumi A Akinbodewa2, Oluseyi A Adejumo2

  • 1Department of Chemical Pathology, Kidney Care Centre, Ondo, Ondo State, Nigeria.

Ghana Medical Journal
|July 18, 2018
PubMed

Insights

Hemodialysis (HD) significantly reduces total antioxidant capacity (TAC) in chronic kidney disease (CKD) patients after one session. However, HD did not affect malondialdehyde (MDA) levels, a marker of lipid peroxidation.

Area of Science:

  • Nephrology
  • Biochemistry
  • Oxidative Stress Research

Background:

  • Oxidative stress is implicated in chronic kidney disease (CKD) pathogenesis and cardiovascular complications.
  • Hemodialysis (HD) may contribute to oxidative stress in CKD patients, but findings are conflicting.

Purpose of the Study:

  • To evaluate the impact of a single HD session on antioxidant capacity and lipid peroxidation in CKD patients.
  • To investigate changes in total antioxidant capacity (TAC) and malondialdehyde (MDA) levels post-HD.

Main Methods:

  • Thirty-six HD-naïve CKD patients underwent a three-hour HD session using polysulfone dialyzers.
  • Blood samples were collected pre- and post-HD.
  • TAC was measured using FRAP assay, and MDA was measured using TBARS assay.

Main Results:

  • A significant decrease in mean TAC was observed post-HD (p<0.001).
  • Malondialdehyde (MDA) levels remained unchanged before and after HD (p>0.05).
  • No association was found between changes in antioxidant status and HD parameters like blood flow rate or ultrafiltration volume.

Conclusions:

  • One session of HD significantly reduces total antioxidant capacity in CKD patients.
  • HD has no significant effect on MDA levels, indicating no increase in lipid peroxidation during the session.

Keywords:
antioxidants capacitychronic kidney diseasehemodialysisoxidative stress

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