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Related Experiment Videos

A serial section study of nuclear pockets containing nuclear material.

F N Ghadially, A Senoo, Y Fuse

    Journal of Submicroscopic Cytology
    |October 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

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    This study distinguishes two types of nuclear pockets in leukaemic lymphocytes: type I (cytoplasmic material) and type II (nuclear material). These distinct lesions do not evolve from one another, clarifying their unique origins.

    Area of Science:

    • Hematology
    • Cell Biology
    • Pathology

    Background:

    • Nuclear pockets are observed in leukaemic lymphocytes.
    • Previous research identified nuclear pockets containing cytoplasmic material.

    Purpose of the Study:

    • To elucidate the three-dimensional morphology and genesis of nuclear pockets containing nuclear material in leukaemic lymphocytes.
    • To differentiate these from nuclear pockets containing cytoplasmic material.

    Main Methods:

    • Serial section study of leukaemic lymphocytes.
    • Three-dimensional reconstruction and morphological analysis.

    Main Results:

    • Two distinct types of nuclear pockets were identified: type I (cytoplasmic material) and type II (nuclear material).

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  • Type I and type II nuclear pockets have separate modes of genesis and do not evolve from each other.
  • Type II nuclear pockets can be open (continuous with nucleus) or closed (separated from nucleus).
  • Observed profiles resembling satellite nuclei in leukaemic cells are artifacts of sectioning type II nuclear pockets.

    • Conclusions:

    • Nuclear pockets containing cytoplasmic material (type I) and nuclear material (type II) are distinct entities.
    • Type II nuclear pockets exhibit variations in their connection to the nucleus (open or closed).
    • Apparent satellite nuclei in leukaemic cells can be explained by cross-sections of type II nuclear pockets.