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Pancreatic Juice and Secretion01:26

Pancreatic Juice and Secretion

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Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
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Acute Pancreatitis I: Introduction01:27

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
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Post-traumatic Stress Disorder01:27

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Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
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Chronic Pancreatitis II: Collaborative Care01:29

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The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
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Post-translational Translocation of Proteins to the RER01:27

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A sizable fraction of proteins destined for ER are first synthesized in the cell cytosol and then transported across the ER membrane–a process called post-translational translocation. Similar to cotranslationally translocated proteins, these proteins also use the Sec translocon complex to enter the ER lumen.
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Related Experiment Video

Updated: Feb 7, 2026

Film Extrusion of Crambe abyssinica/Wheat Gluten Blends
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Post pancreatitis/cholecystectomy gluten intolerance.

Ivan Tang1, George MacFaul1, Ravi Madhotra1

  • 1Department of Gastroenterology, Hepatology and Nutrition, Milton Keynes University Hospital, United Kingdom.

Gastroenterology and Hepatology From Bed to Bench
|July 18, 2018
PubMed
Summary

A patient with persistent gastrointestinal issues, initially diagnosed as Irritable Bowel Syndrome (IBS), found relief through gluten and lactose exclusion diets. Subsequent gluten challenges confirmed sensitivity, suggesting misdiagnosis in some IBS cases.

Keywords:
Gluten sensitivityNon-coeliacPost-cholecystectomy gluten intolerancePost-pancreatitis

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Area of Science:

  • Gastroenterology
  • Clinical Nutrition
  • Dietary Interventions

Background:

  • Gastrointestinal (GI) symptoms are common and can significantly impact quality of life.
  • Endoscopic Retrograde Cholangiopancreatography (ERCP) is a procedure used for diagnosing and treating bile duct issues.
  • Cholelithiasis, or gallstones, can lead to complications requiring intervention.

Observation:

  • A patient experienced severe, life-limiting GI symptoms post-ERCP for bile duct stones and cholecystectomy.
  • Initial diagnosis of Irritable Bowel Syndrome (IBS) and medication treatment yielded no significant improvement.
  • A gluten and lactose exclusion diet led to complete recovery to the patient's premorbid state.

Findings:

  • Gluten challenge after dietary improvement triggered symptom exacerbation, indicating gluten sensitivity.
  • The patient's symptoms resolved with a gluten and lactose-free diet, suggesting these intolerances were the primary cause.
  • This case highlights potential misdiagnosis of gluten sensitivity as IBS in clinical practice.

Implications:

  • Gluten and lactose exclusion diets may be beneficial for patients with unexplained GI symptoms.
  • Re-evaluation of IBS diagnoses to include potential gluten sensitivity is warranted.
  • Further research into dietary interventions for functional GI disorders is crucial.