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Modulation of cell communication and carcinogenesis
The Japanese Journal of Physiology
|January 1, 1985
Summary
Tumor promoters inhibit cell communication, a key factor in cancer development. This suggests that blocking cell communication may be crucial in carcinogenesis, with kinases potentially regulating this process.
Area of Science:
- Oncology
- Cell Biology
- Biochemistry
Background:
- Cell communication is vital for normal cell growth and differentiation.
- Recent studies link tumor promoters to the inhibition of intercellular communication.
- This inhibition is observed in the context of carcinogenesis.
Purpose of the Study:
- To review recent studies on the role of cell communication in cancer induction.
- To explore the link between tumor promoters, cell communication inhibition, and carcinogenesis.
- To discuss the potential role of kinases in regulating cell communication during cancer promotion.
Main Methods:
- Review of recent scientific literature on cell communication and cancer.
- Analysis of studies investigating the effects of tumor promoters on cell communication.
- Examination of in vitro carcinogenesis models, specifically using Balb/c 3T3 cells.
Main Results:
- Tumor promoters, such as phorbol esters, inhibit cell communication.
- Inhibition of cell communication by phorbol esters correlates with enhanced in vitro carcinogenesis.
- Calcium/phospholipid-dependent kinase and cAMP-dependent kinase are implicated in regulating cell communication.
Conclusions:
- Blocked cell communication is strongly suggested to play a causative role in carcinogenesis.
- Disturbances in kinase systems may be responsible for the promotion phase of cancer.
- Further research is needed to directly demonstrate the physiological role of cell communication in carcinogenesis and identify gap junction-permeable molecules.