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Functional and structural brain networks in posterior cortical atrophy: A two-centre multiparametric MRI study
Federica Agosta1, Gorana Mandic-Stojmenovic2, Elisa Canu1
1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, via Olgettina 60, 20132 Milan, Italy.
Neuroimage. Clinical
|July 18, 2018
Summary
Posterior cortical atrophy (PCA) involves widespread brain damage, affecting white matter tracts and functional connectivity. Alterations worsen with disease progression, impacting visual, default mode, and other brain networks.
Area of Science:
- Neuroscience
- Neurology
- Medical Imaging
Background:
- Posterior cortical atrophy (PCA) is a neurodegenerative syndrome characterized by progressive visual and cognitive decline.
- Understanding the underlying structural and functional brain changes is crucial for diagnosis and management.
Purpose of the Study:
- To identify structural and functional brain connectivity alterations in patients with posterior cortical atrophy (PCA).
- To investigate how these alterations change with disease progression.
Main Methods:
- Utilized diffusion tensor (DT) MRI for white matter (WM) tract analysis.
- Employed resting-state (RS) functional MRI to assess brain network connectivity.
- Applied voxel-based morphometry to investigate grey matter (GM) atrophy.
Main Results:
- PCA patients exhibited GM atrophy in occipital-temporal-parietal regions.
- Identified WM damage in the corpus callosum, superior longitudinal fasciculi (SLF), and inferior longitudinal fasciculi (ILF).
- Observed decreased functional connectivity in visual and default mode networks (DMN), worsening with disease severity.
Conclusions:
- PCA involves distributed WM damage and progressive functional connectivity decline.
- Alterations spread from occipital to frontostriatal regions, likely via WM connections.
- Combined DT-MRI and RS-fMRI may aid in monitoring PCA progression.
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