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Deciphering Non-coding RNAs in Cardiovascular Health and Disease
Anindita Das1, Arun Samidurai1, Fadi N Salloum1
1Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, VA, United States.
Frontiers in Cardiovascular Medicine
|July 18, 2018
Summary
Non-coding RNAs (ncRNAs) are revolutionizing cardiovascular disease (CVD) research. These molecules show promise as novel therapeutic targets and biomarkers for diagnosing and treating various heart conditions.
Area of Science:
- Genomics and Molecular Biology
- Cardiovascular Medicine
Background:
- Non-coding RNAs (ncRNAs), once dismissed as
Purpose of the Study:
- To review the current understanding of ncRNA roles in cardiovascular health and disease.
- To explore ncRNAs as potential therapeutic targets and biomarkers for CVDs.
- To discuss cardioprotective signaling pathways involving the non-coding genome.
Main Methods:
- Literature review of recent discoveries and breakthroughs in ncRNA research.
- Analysis of ncRNA involvement in various cardiovascular conditions.
- Discussion of therapeutic and diagnostic potential of ncRNAs.
Main Results:
- ncRNAs, including microRNAs (miRNAs) and long ncRNAs (lncRNAs), play critical roles in epigenetic regulation, atherosclerosis, ischemia/reperfusion injury, cardiac remodeling, and diabetic cardiomyopathy.
- Emerging evidence supports the use of ncRNAs as therapeutic agents and diagnostic/prognostic biomarkers for CVDs.
- Specific cardioprotective signaling pathways activated by ncRNAs have been identified.
Conclusions:
- ncRNAs represent a significant advancement in cardiovascular research, offering new avenues for treatment and diagnosis.
- Further research is needed to overcome limitations and fully realize the therapeutic potential of ncRNAs in CVD management.
Keywords:
atherosclerosisdiabetic cardiomyopathyhypertrophylong non-coding RNAmicroRNAmyocardial infarctionMore Related Videos
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