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Retinal oxygen metabolism in patients with mild cognitive impairment

Olof Birna Olafsdottir1,2, Hrafnhildur Sif Saevarsdottir2, Sveinn Hakon Hardarson2

  • 1Department of Ophthalmology, Landspitali - National University Hospital, Reykjavik, Iceland.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
|July 18, 2018
PubMed
Abstract

Insights

Retinal vessel oxygen saturation is elevated in individuals with mild cognitive impairment (MCI), a predementia stage of Alzheimer's disease. This suggests altered retinal oxygen metabolism in early stages of the disease.

Area of Science:

  • Ophthalmology
  • Neurology
  • Medical Diagnostics

Background:

  • Previous research indicated increased retinal vessel oxygen saturation in Alzheimer's disease.
  • Mild cognitive impairment (MCI) represents a predementia stage of Alzheimer's disease.

Purpose of the Study:

  • To investigate if elevated retinal vessel oxygen saturation is present in individuals with MCI compared to healthy controls.

Main Methods:

  • Noninvasive retinal oximetry (Oxymap T1) was used to measure retinal vessel oxygen saturation.
  • 42 patients with MCI and 42 age-matched healthy individuals participated.

Main Results:

  • MCI patients exhibited significantly higher arteriolar and venular oxygen saturation compared to healthy individuals.
  • A decreased arteriovenous oxygen saturation difference was observed in MCI patients.

Conclusions:

  • Elevated retinal oxygen saturation and reduced arteriovenous difference in MCI may indicate reduced oxygen extraction by retinal tissues.
  • These findings suggest potential alterations in retinal oxygen metabolism during the MCI stage.
Keywords:
Alzheimer's diseaseMild cognitive impairmentOximetryOxygen saturationRetinaRetinal vesselsSpectrophotometry

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