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Updated: Feb 7, 2026
10:46
A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
11.1K
Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: A Network Meta-Analysis
Rosa C Lucchetta1, Fernanda S Tonin1, Helena H L Borba1
1Pharmacy, Federal University of Paraná, Curitiba, Brazil.
CNS Drugs
|July 18, 2018
Summary
Alemtuzumab, natalizumab, and ocrelizumab show the highest efficacy for relapsing-remitting multiple sclerosis (RRMS) based on current evidence. Further research is needed to fully understand the safety profiles of these disease-modifying therapies (DMTs).
Area of Science:
- Neurology
- Immunology
Background:
- Numerous disease-modifying therapies (DMTs) exist for relapsing-remitting multiple sclerosis (RRMS).
- The comparative efficacy and safety of traditional versus newer DMTs remain incompletely understood.
Purpose of the Study:
- To synthesize evidence on the clinical outcomes of DMTs in adult patients with RRMS.
- To compare the efficacy and safety of various DMTs for RRMS.
Main Methods:
- Conducted Bayesian network meta-analyses of randomized clinical trials for DMTs in RRMS.
- Included 33 studies, utilizing SUCRA and GRADE for therapy ranking and evidence quality assessment.
Main Results:
- Alemtuzumab, natalizumab, and ocrelizumab demonstrated the highest efficacy in reducing the annualized relapse rate (ARR).
- No significant differences in ARR reduction were found among these three top-performing DMTs.
- Discontinuation rates due to adverse events were similar across most therapies, with alemtuzumab showing lower discontinuation than interferon-1a intramuscular.
Conclusions:
- Alemtuzumab, natalizumab, and ocrelizumab offer the highest efficacy for RRMS patients.
- Further meta-analyses are recommended to thoroughly evaluate the safety and adverse event profiles of DMTs.
- A three-tiered classification (high, intermediate, low efficacy) is suggested for DMTs based on their effectiveness.
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