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The large ribosomal subunit has several important structures essential to translation. These include the peptidyl transferase center (PTC) - which is the site where the peptide bond is formed - and a large, internal, water-filled tube through which the nascent polypeptide moves. This latter structure is called the Peptide Exit Tunnel, and it begins at the PTC and spans the body of the large ribosomal subunit. During translation, as the nascent polypeptide chain is synthesized, it passes through...

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Related Experiment Video

Updated: Jun 18, 2026

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C UV-C Damage

Published on: February 15, 2020

To be or not to be.

Zhe Zhang¹, Elisabeth Hessmann¹

¹Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Gottingen, Germany.

|July 18, 2018

Summary

Chromatin remodeling, a key epigenetic process, influences cell fate decisions. This study shows how these changes guide specific cell type development.

Area of Science:

Epigenetics and Developmental Biology
Cellular Differentiation
Chromatin Dynamics

Background:

Cell fate determination is crucial for tissue development and function.
Epigenetic mechanisms, including chromatin remodeling, are known to regulate gene expression.
The specific role of chromatin remodeling in acinar cell lineage commitment requires further elucidation.

Purpose of the Study:

To investigate the role of chromatin remodeling in directing acinar cell fate decisions.
To identify key chromatin remodeling events associated with acinar cell differentiation.

Main Methods:

Utilized advanced genomic and epigenomic profiling techniques.
Employed cellular and molecular biology assays to track cell fate.
Analyzed chromatin accessibility and histone modification patterns during differentiation.

Keywords:

Arid1a Kras SWI/SNF acinar cell cancer biology chromatin remodeling protein mouse pancreatic cancer

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Main Results:

Specific patterns of chromatin remodeling were observed to precede and correlate with acinar cell fate commitment.
Key regulatory regions of genes critical for acinar cell identity showed dynamic changes in chromatin structure.
Inhibition of specific chromatin remodelers altered the trajectory of cell fate decisions.

Conclusions:

Chromatin remodeling is a critical driver of acinar cell fate decisions.
Targeting chromatin remodeling pathways may offer novel strategies for controlling cell differentiation in regenerative medicine.