Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathologic analysis of primary brain tumors.

R D McComb, P C Burger

    Neurologic Clinics
    |November 1, 1985
    PubMed
    Summary

    This study classifies diffuse astrocytomas based on anaplasia, noting prognosis depends on histology, patient age, tumor location, and resection extent. Glial fibrillary acidic protein (GFAP) aids in diagnosing astrocytic neoplasms.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Progressive multifocal leukoencephalopathy in a patient without immunodeficiency.

    Neurology·2011
    Same author

    Seronegative naturally acquired West Nile virus encephalitis in a renal and pancreas transplant recipient.

    Transplant infectious disease : an official journal of the Transplantation Society·2010
    Same author

    Clinical, neuropathological and genotypic variability in SNCA A53T familial Parkinson's disease. Variability in familial Parkinson's disease.

    Acta neuropathologica·2008
    Same author

    Diagnostic and prognostic value of glycosyltransferase mRNA in glioblastoma multiforme patients.

    Neuropathology and applied neurobiology·2006
    Same author

    Pilomyxoid astrocytoma in a patient with neurofibromatosis.

    Pediatric blood & cancer·2005
    Same author

    Autosomal dominant parkinsonism associated with variable synuclein and tau pathology.

    Neurology·2004

    Area of Science:

    • Neuro-oncology
    • Pathology
    • Neurosurgery

    Background:

    • Diffuse astrocytomas are graded by anaplasia into astrocytoma, anaplastic astrocytoma, and glioblastoma multiforme.
    • Juvenile pilocytic astrocytomas are distinct from diffuse fibrillary astrocytomas and have a better prognosis.
    • Prognosis is influenced by histology, patient age, tumor location, and extent of surgical resection.

    Purpose of the Study:

    • To classify diffuse astrocytomas based on anaplasia.
    • To differentiate gliomas from metastatic tumors based on invasion patterns.
    • To highlight the diagnostic utility of Glial Fibrillary Acidic Protein (GFAP) in identifying astrocytic and ependymal tumors.

    Main Methods:

    • Histologic classification of astrocytomas based on tumor anaplasia.
    • Analysis of tumor invasion patterns to distinguish gliomas from other malignancies.
    • Immunohistochemical detection of Glial Fibrillary Acidic Protein (GFAP).

    Main Results:

    • Astrocytomas are categorized into three groups: astrocytoma, anaplastic astrocytoma, and glioblastoma multiforme.
    • Malignant gliomas exhibit variable invasion patterns, distinguishing them from metastatic carcinomas and sarcomas.
    • GFAP presence indicates astrocytic or ependymal differentiation, aiding in distinguishing gliomas from other tumor types.

    Conclusions:

    • Astrocytoma classification is based on anaplasia, with prognosis influenced by multiple factors.
    • Understanding invasion patterns is crucial for glioma diagnosis.
    • GFAP is a valuable marker for diagnosing and characterizing astrocytic and ependymal neoplasms.

    Related Experiment Videos