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Association betweenGREM2 gene polymorphism with osteoporosis and osteopenia in postmenopausal women

Adam Kamiński1, Anna Bogacz2, Izabela Uzar3

  • 1Department of Orthopaedics and Traumatology, Independent Public Clinical Hospital No. 1, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, Poland.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|July 18, 2018
PubMed
Abstract

Insights

The TT genotype of the GREM2 gene may protect against osteoporosis in postmenopausal women. This genotype was dominant in healthy women, while TC was more common in those with osteopenia and osteoporosis.

Area of Science:

  • Genetics
  • Bone Biology
  • Osteoporosis Research

Background:

  • Osteoporosis is characterized by bone mass loss and structural disturbances.
  • Gremlin-2 (GREM2) is an antagonist of bone morphogenetic proteins (BMPs), influencing osteogenesis and osteoblast differentiation.

Purpose of the Study:

  • To investigate the association between GREM2 gene polymorphism and osteoporosis in postmenopausal women.
  • To determine if GREM2 gene polymorphism is a predisposing factor for osteoporosis development.

Main Methods:

  • A study involving 675 Polish postmenopausal women (109 osteopenia, 333 osteoporosis, 233 healthy controls).
  • Statistical evaluation of GREM2 polymorphism effects on bone mineral density (T-score, Z-score, L2L4BMD), body mass, BMI, and birth weight.

Main Results:

  • No statistical significance in genotype frequencies (TT, TC, CC) of GREM2 rs4454537 polymorphism between study groups.
  • Statistical significance in birth weight was observed between TT/TC and TT/CC genotypes in control vs. osteoporosis groups.
  • Body mass analysis in osteoporotic women showed statistical significance between TT/CC and TT/TC genotypes.

Conclusions:

  • The TC genotype was most frequent in women with osteopenia and osteoporosis.
  • The TT genotype was dominant in healthy women, suggesting a protective role against osteoporosis.
  • The TT genotype may be a protective factor for developing osteoporosis.
Keywords:
GREM2 geneGene polymorphismMenopauseOsteoporosis

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