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Vera L M Silva1, J Elguero2, Artur M S Silva1

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Area of Science:

  • Medicinal Chemistry
  • Drug Discovery
  • Organic Synthesis

Background:

  • The development of novel antioxidant compounds is a key area in medicinal chemistry.
  • Numerous structurally diverse compounds with antioxidant potential have been synthesized and published.
  • Pyrazole derivatives are increasingly investigated for their therapeutic properties.

Purpose of the Study:

  • To review the current state-of-the-art in the development of antioxidant compounds featuring the pyrazole pharmacophore.
  • To analyze the relationship between the pyrazole core and antioxidant activity based on published literature from 2000-2017.
  • To establish structure-activity relationships for designing more potent pyrazole-based antioxidant agents.

Main Methods:

  • Comprehensive literature search of scientific papers published between 2000 and 2017.
  • Analysis of chemical structures containing the pyrazole core, either alone or in combination with other pharmacophores.
  • Evaluation of reported antioxidant activities and exploration of structure-activity relationships.

Main Results:

  • A significant increase in the number of publications on pyrazole-containing antioxidants since 2000.
  • Identification of various pyrazole derivatives exhibiting promising antioxidant potential.
  • Preliminary structure-activity relationships were identified, linking specific structural features to antioxidant efficacy.

Conclusions:

  • The pyrazole scaffold is a valuable pharmacophore for developing new antioxidant agents.
  • Further research into structure-activity relationships can optimize the design of novel, potent antioxidants.
  • Pyrazole-based compounds hold significant promise as drug candidates for conditions associated with oxidative stress.