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Updated: Feb 7, 2026
07:07
Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
Published on: February 21, 2016
11.0K
Planar cell polarity in organ formation
Deborah J Henderson1, David A Long2, Charlotte H Dean3
1Cardiovascular Research Centre, Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UK.
Current Opinion in Cell Biology
|July 18, 2018
Summary
The planar cell polarity (PCP) pathway guides cell behavior in development and organ formation. Disruptions in PCP genes are increasingly linked to adult diseases, highlighting its critical role in health.
Area of Science:
- Developmental Biology
- Cell Biology
- Genetics
Background:
- The planar cell polarity (PCP) pathway is crucial for regulating cell orientation and collective cell behaviors.
- It directs fundamental morphogenetic processes like convergent extension and collective cell migration during embryonic development.
Purpose of the Study:
- To review the significant role of the PCP pathway in organogenesis.
- To focus on the involvement of PCP in the development of lungs, kidneys, and heart.
- To highlight emerging evidence linking PCP gene mutations to adult diseases.
Main Methods:
- Literature review of studies on PCP pathway in organogenesis.
- Analysis of research on PCP gene mutations and associated adult diseases.
Main Results:
- The PCP pathway plays a prominent role in the development of major organs including the lungs, kidneys, and heart.
- Emerging evidence suggests a connection between PCP gene mutations and various adult-onset diseases.
Conclusions:
- The PCP pathway is essential for normal organogenesis.
- Dysregulation of the PCP pathway, through genetic mutations, may contribute to the pathogenesis of adult diseases, warranting further investigation.
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