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Updated: Feb 7, 2026

Author Spotlight: Exploring Cellular Zinc Regulation Through ZnT1 Functionality
Published on: June 2, 2023
Mechanochemical Activation of Zinc and Application to Negishi Cross-Coupling
Qun Cao1, Joseph L Howard1, Emilie Wheatley1
1School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3EQ, UK.
Abstract:
A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross-coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp3 )-C(sp2 ) and C(sp2 )-C(sp2 ) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.
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