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Qualitative and Quantitative Characteristics of Selected Bacterial Groups in Children with Inflammatory Bowel

Dorota Roszak1, Mirosława Gałęcka1, Wojciech Cichy1

  • 1First Department of Pediatrics; Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland.

Polish Journal of Microbiology
|July 18, 2018
PubMed

Insights

Changes in gut bacteria in children with inflammatory bowel diseases (IBD) correlate with disease activity and inflammation markers. Differences in microflora between Crohn's disease and ulcerative colitis suggest distinct causes.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Pediatrics

Background:

  • Inflammatory bowel diseases (IBD) encompass Crohn's disease and ulcerative colitis, characterized by chronic gut inflammation.
  • The gut microbiome plays a crucial role in IBD pathogenesis, but its specific alterations in pediatric populations require further investigation.

Purpose of the Study:

  • To evaluate qualitative and quantitative changes in the bacterial ecosystem of children diagnosed with IBD.
  • To correlate these microbial changes with clinical disease activity and fecal inflammatory markers.

Main Methods:

  • Analysis of stool samples from 109 children with IBD.
  • Quantification of selected bacteria and measurement of fecal calprotectin, lactoferrin, and M2-PK concentrations.

Main Results:

  • The abundance of specific microorganisms was found to be dependent on the clinical activity of the disease.
  • Significant correlations were observed between the number of selected microorganisms and fecal concentrations of inflammatory markers.
  • Distinct patterns of microflora disturbance were identified in patients with Crohn's disease compared to those with ulcerative colitis.

Conclusions:

  • Gut microflora alterations in pediatric IBD are linked to disease severity and inflammation.
  • Observed differences in microbiome disturbances between Crohn's disease and ulcerative colitis may indicate divergent etiological pathways for these conditions.

Keywords:
Crohn’s diseaseIBDM2-PKfaecal bacteriainflammatory markers

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