Continuous behavioral tracing-based online functional brain mapping with intracranial electroencephalography
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Updated: Feb 7, 2026

Performing Behavioral Tasks in Subjects with Intracranial Electrodes
Published on: October 2, 2014
Jianbin Wen1, Tao Yu2, Xueyuan Wang2
1State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, People's Republic of China.
Abstract:
Intracranial electroencephalography (iEEG) has proven to be a reliable tool in clinical functional brain mapping. While iEEG signals are believed to be highly informative, making online or real-time functional mapping possible, the utilization of corresponding behavioral information in traditional trial-based paradigms is typically low. This imbalance has limited the efficiency and effectiveness in current iEEG-based functional mapping approaches.
Objective:
In the current study, we were to investigate whether using more dedicate behavioral information can improve iEEG-based functional mapping.
Approach:
We continuously monitored behavioral outputs of patients during iEEG recording, transformed them into regressors, and assessed their correlations with iEEG signals.
Main Results:
Functional cortical sites identified in preliminary test using the proposed method showed considerable consistency with the results from electrical cortical stimulation (ECS) as well as a trial-based method. Continuous behavioral tracing yielded more dependency to neural signals than sole event markers-derived regressor. Based on this, we successfully performed online functional brain mapping during five neurosurgery operations, which yielded satisfactory results.
Significance:
In the present study, we showed the utilization of continuous behavioral tracing can improve the efficiency of iEEG-based functional brain mapping. We then demonstrated this approach is adequate for multi-session intraoperative functional assessment within short time span, which is of considerable clinical value.
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