Related Experiment Video
Updated: Feb 7, 2026
07:49
High-Resolution C. elegans Imaging Across All Larval Stages
Published on: May 23, 2025
1.3K
Imaging biomarkers and staging in IPF.
1Department of Radiology, King's College Hospital Foundation Trust, Denmark Hill, Brixton, London SE5 9RS, United Kingdom.
Current Opinion in Pulmonary Medicine
|July 18, 2018
Summary
Computer-based analysis of high-resolution computed tomography (HRCT) offers objective disease quantification for idiopathic pulmonary fibrosis (IPF). This approach overcomes the subjectivity of visual interpretation, improving prognostic accuracy and clinical trial stratification.
Area of Science:
- Pulmonary Medicine
- Radiology
- Medical Imaging Analysis
Background:
- Idiopathic pulmonary fibrosis (IPF) diagnosis and prognosis rely heavily on HRCT imaging.
- Visual interpretation of HRCT patterns in IPF is subjective and prone to interobserver variability.
- Objective quantification methods are needed to improve diagnostic accuracy and prognostic prediction in IPF.
Purpose of the Study:
- To review challenges in visual HRCT interpretation for IPF.
- To describe current computer-based technologies for objective HRCT quantification in IPF.
- To discuss future directions in imaging biomarker research for IPF.
Main Methods:
- Review of current literature on HRCT analysis in IPF.
- Description of computer-based imaging analysis techniques.
- Discussion of technological advancements in quantitative imaging.
Main Results:
- Computer-based quantification provides objective and reproducible data for IPF.
- Objective HRCT data can predict mortality and disease decline in IPF patients.
- These technologies can aid in stratifying patients for clinical trials.
Conclusions:
- Computer-based HRCT evaluation is the future of imaging biomarker research in IPF.
- Development requires large, annotated imaging datasets for tool development and validation.
- Prospective trials are essential for validating imaging biomarkers in IPF.
Related Concept Videos
01:26Stages of Infection
65.3K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.3K
01:22Stages of General Anesthesia
1.7K
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
1.7K
01:22Stages of Sleep
1.5K
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
1.5K
01:16Psychosexual Stages of Personality: Oral
3.2K
The oral stage is the initial phase of Sigmund Freud's theory of psychosexual development, occurring from birth to approximately 12 to 18 months. During this period, the infant's mouth serves as the primary source of pleasure, with actions such as sucking, chewing, biting, and drinking playing a crucial role in reducing tension. These activities are essential not only for nourishment but also for the infant's psychological and emotional satisfaction.
Weaning, typically occurring...
Weaning, typically occurring...
3.2K
01:26Psychosexual Stages of Personality: Anal
4.1K
Sigmund Freud's theory of psychosexual development describes the anal stage as occurring between 18 months and three years of age. During this period, children derive pleasure from controlling and releasing their bowel movements. However, they quickly learn that societal expectations impose restrictions on when and where this can happen. This stage marks a critical point where children begin to develop a sense of control and mastery over their bodily functions, as well as their broader...
4.1K
01:12Psychosexual Stages of Personality: Phallic
1.9K
The third stage of psychosexual development proposed by Freud is the phallic stage, occurring between the ages of 3 and 6. During this period, children become aware of their bodies and the differences between males and females. The erogenous zone in this stage is the genitals, and conflicts arise as children develop desires toward the opposite-sex parent. Boys experience the Oedipus complex, where they desire their mother and view their father as a rival. This leads to castration anxiety, the...
1.9K