[Corrigendum] Neurotoxin β‑N‑methylamino‑L‑alanine induces endoplasmic reticulum stress‑mediated neuronal apoptosis

Area of Science:

• Neuroscience
• Molecular Biology
• Cellular Stress Response

Background:

• Beta-N-methylamino-L-alanine (BMAA) is a neurotoxin implicated in neurodegenerative diseases.
• Endoplasmic reticulum (ER) stress is a key mechanism in BMAA-induced neuronal death.
• Heat shock protein 70 (HSP70) is a known cellular protectant against various stressors.

Purpose of the Study:

• To investigate the role of HSP70 in mitigating ER stress-mediated neuronal death induced by BMAA.
• To present a corrected figure (Fig. 4A) clarifying the experimental results.

Main Methods:

• Overexpression of HSP70 in neuronal cells.
• Induction of ER stress using BMAA.
• Assessment of neuronal viability and cell death markers.
• Western blot analysis to evaluate protein expression.

Main Results:

• The corrected Fig. 4A demonstrates that HSP70 overexpression suppresses BMAA-induced neuronal death.
• Specific band images in the HA panel of Fig. 1A were identified as incorrectly compiled.
• The corrected figure accurately represents the protective effect of HSP70 against BMAA toxicity.

Conclusions:

• HSP70 overexpression effectively protects against ER stress-induced neuronal death caused by BMAA.
• The correction of Fig. 4A ensures accurate data presentation without impacting the study's overall findings or conclusions.