Related Experiment Video

Updated: Feb 7, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
08:30

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

14.7K

Acute phase markers in obese children and adolescents with metabolic disorders

Idalia Cura-Esquivel1, Paula Cordero-Pérez2, Liliana Torres-González2

  • 1Departamento de Pediatría, Hospital Universitario "Dr. José E. González". idaliaaracely2008@hotmail.com.

Archivos Argentinos De Pediatria
|July 18, 2018
PubMed

Insights

Obese children show increased C-reactive protein. Metabolic syndrome is linked to higher apolipoprotein A-1 and haptoglobin, while hepatic steatosis correlates with elevated alpha-2-macroglobulin.

Area of Science:

  • Pediatric Endocrinology
  • Clinical Biochemistry
  • Public Health

Background:

  • Obesity is a global health crisis and a leading non-communicable chronic disease.
  • Obesity is characterized by elevated inflammatory markers, including acute phase proteins and cytokines.

Purpose of the Study:

  • To evaluate acute phase protein levels in obese children and adolescents.
  • To investigate the association between these proteins and the presence of hepatic steatosis and metabolic syndrome.

Main Methods:

  • Study included 45 obese children (BMI ≥ 95th percentile) aged 5.0-15.5 years.
  • Measured C-reactive protein, haptoglobin, alpha-2-macroglobulin, and apolipoprotein A-1.
  • Assessed hepatic steatosis using ultrasound.

Main Results:

  • C-reactive protein levels were elevated in all obese participants.
  • Metabolic syndrome was associated with increased apolipoprotein A-1 and haptoglobin.
  • Hepatic steatosis correlated with significantly higher alpha-2-macroglobulin and C-reactive protein.

Conclusions:

  • Obesity in children is associated with increased systemic inflammation, indicated by elevated C-reactive protein.
  • Specific acute phase proteins may serve as biomarkers for metabolic complications like metabolic syndrome and hepatic steatosis in obese youth.
Abstract

Keywords:
C-reactive proteinalpha-2-macroglobulinsapolipoprotein A-1haptoglobinsobesity

More Related Videos

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder09:13

Testing Sensory and Multisensory Function in Children with Autism Spectrum Disorder

Published on: April 22, 2015

17.2K
Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia13:08

Measurement of Fronto-limbic Activity Using an Emotional Oddball Task in Children with Familial High Risk for Schizophrenia

Published on: December 2, 2015

9.5K

Related Concept Videos

Drug Metabolism: Phase I Reactions01:17

Drug Metabolism: Phase I Reactions

A phase I reaction is a biochemical process that introduces a functionally reactive polar group to a substance. This transformation predominantly occurs in the liver, facilitated by the cytochrome P450 system of hemoproteins situated in the lipophilic endoplasmic reticulum of cells. The metabolite generated through this process can have varying polarities. If it is sufficiently polar, it can be easily excreted in the urine due to its water compatibility. However, if the metabolite is nonpolar,...
5.0K
Drug Metabolism: Phase II Reactions01:14

Drug Metabolism: Phase II Reactions

Phase II reactions are essential for the detoxification and elimination of drugs from the body. These reactions involve the conjugation of parent drugs or their phase I metabolites with endogenous molecules, resulting in more hydrophilic drug conjugates. The primary conjugation reactions in this phase are sulfation and glucuronidation. Both sulfation and glucuronidation typically produce biologically inactive metabolites. However, in some cases involving prodrugs, active metabolites may be...
5.2K
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
191
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.4K
What is Metabolism?00:52

What is Metabolism?

Overview
132.0K
Cognitive Development During Adolescence01:18

Cognitive Development During Adolescence

During adolescence, individuals experience significant cognitive development that enhances their understanding of others' emotions and thoughts, known as cognitive empathy. This period is marked by an increased ability to adapt to others' perspectives and a more nuanced understanding of others' mental states, a skill that is foundational for social problem-solving and conflict avoidance. The development of cognitive empathy relies heavily on the theory of mind — the...
628