Related Experiment Video
Updated: Feb 7, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
Published on: May 30, 2025
Monosomy 9p24 in two non-related patients as result of a translocation (2;9)
Nayla Y León-Carlos1, Constanza García-Delgado1, Ariadna B Morales-Jiménez1
1Departamento de Genética, Hospital Infantil de México Federico Gómez, Ciudad de México, México.
Abstract:
In patients with malformations and delayed psychomotor development it is important to discard chromosomopathies. Balanced reciprocal translocations are the most frequent chromosomopathies present in 1:500 live newborns. In general, carriers have normal phenotype, but they may have infertility, abortions or children with congenital malformations. The reciprocal translocation between chromosomes 2 and 9 can lead to offspring with monosomies and trisomies of these chromosomes. Short arm monosomy of chromosome 9 may present delayed psychomotor development, trigonocephaly, facial dysmorphia and genital abnormalities. We reviewed GTG karyotype records from our Institution to identify cases with chromosomes 2 and/or 9 alterations from 2005 to 2014. We describe two cases with monosomy 9p secondary to a translocation between chromosomes 2 and 9. The patients share features of monosomy 9p24-pter, however the genotypephenotype correlation is complex due to the extension of the involved segments. We emphasize the importance of chromosomal diagnosis to offer genetic assessment.
Related Concept Videos
Resultant of a General Distributed Loading
Examples such as load distribution due to wind and load distribution on a bridge illustrate how this concept is used to analyze and design safe, reliable structures under variable loading conditions. Most structures, such as residential buildings, bridges, and towers, are...
Resultant Moment: Scalar Formulation
To determine the resultant moment, the moments caused by all the forces in a system in the x-y plane are considered. Positive moments are typically...
Resultant Moment: Vector Formulation
The resultant moment of a system of forces can be calculated through vector formulation. For example, if we consider...
Cotranslational Protein Translocation
Sec61 channel partners for cotranslational translocation
During cotranslational translocation, the Sec61 channel partners with the signal recognition particle (SRP), the signal recognition particle receptor (SR), and the ribosomes to transport the nascent polypeptide chain...
Energy to Drive Translocation
Generally, polypeptides are unfolded by two distinct...
Translocation of Proteins into the Mitochondria
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...

