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Updated: Feb 7, 2026

Murine Model of Wound Healing
Published on: May 28, 2013
Topical oxygen therapy stimulates healing in difficult, chronic wounds: a tertiary centre experience
Hanna Kaufman1, Maxim Gurevich2, Eran Tamir3
1Head of Department; 1Northern District Trauma & Wound Clinics Division, "Maccabi" Health Care Services.
Objective:
Oxygen plays a central role in wound healing. Recent technological advances have miniaturised oxygen delivery systems, with novel topical oxygen therapy allowing patients to receive oxygen therapy 24 hours a day while remaining completely mobile. Here we aim to examine the efficacy and safety of continuous topical oxygen diffusion in a 'real-world' setting.
Methods:
Topical oxygen therapy (TOT) was evaluated in patients with chronic, non-healing wounds in a tertiary referral specialist clinic.
Results:
The mean wound duration before TOT was 15 months. Regardless of treatment duration, in this previously non-healing group complete wound closure was observed in 32% of the total patients treated with the TOT device. However, optimal wound healing occurred when the device was used for >25 days, with an 83% wound area reduction and 47% wound closure rate seen in venous leg ulcers (VLUs) and a 74% reduction and a 57% wound closure rate in arterial foot ulcers.
Conclusion:
Use of TOT in chronic wounds stimulates a healing state. In our study, almost half of the previously non-healing wounds closed.
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