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[Vitamin D deficiency rickets: single-dose therapy versus continuous therapy].
Padiatrie Und Padologie
|January 1, 1985
Summary
Both single high-dose and continuous low-dose vitamin D3 treatments are effective for vitamin D-deficiency rickets (VDR). Neither treatment showed a superior effect, indicating both regimens are recommendable for VDR management.
Area of Science:
- Endocrinology
- Pediatrics
- Nutritional Science
Context:
- Vitamin D-deficiency rickets (VDR) is a significant health concern requiring effective treatment strategies.
- Assessing the comparative efficacy of different vitamin D3 administration protocols is crucial for clinical practice.
Purpose:
- To compare the effectiveness of a massive single-dose oral treatment versus a continuous low-dose vitamin D3 treatment for VDR.
- To evaluate serum levels of calcium, phosphorus, alkaline phosphatase, calcitriol, parathyroid hormone, and calcitonin in response to both treatment regimens.
Summary:
- Ten patients with VDR were divided into two groups: one receiving a massive single dose (400,000 IU) and the other continuous low-dose (9600 IU/day for 18 days) vitamin D3.
- Serum markers showed no significant differences between groups for calcium, phosphorus, and alkaline phosphatase.
- The single-dose group exhibited a faster normalization of parathyroid hormone and a quicker increase in calcitriol levels.
Impact:
- Both treatment regimens demonstrated effectiveness in managing VDR, with no unequivocal superiority of one over the other.
- The findings support the recommendation of both massive single-dose and continuous low-dose vitamin D3 treatments for VDR.
- This study contributes to optimizing therapeutic approaches for vitamin D-deficiency rickets.