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Death from Transfusion-Transmitted Anaplasmosis, New York, USA, 2017

Ruchika Goel, Lars F Westblade, Debra A Kessler

    Emerging Infectious Diseases
    |July 18, 2018
    PubMed

    Insights

    A fatal case of transfusion-transmitted anaplasmosis occurred in a 78-year-old man. He died from septic shock two weeks after receiving contaminated erythrocytes harboring Anaplasma phagocytophilum.

    Area of Science:

    • Infectious Diseases
    • Hematology
    • Transfusion Medicine

    Background:

    • Anaplasmosis is a tick-borne bacterial infection caused by Anaplasma species.
    • Transfusion-transmitted infections pose a significant risk in healthcare settings.
    • Early diagnosis and prevention of Anaplasma phagocytophilum transmission are crucial.

    Observation:

    • A 78-year-old male patient developed severe illness following a perioperative blood transfusion.
    • The patient received erythrocytes infected with Anaplasma phagocytophilum.

    Findings:

    • The patient exhibited symptoms of septic shock and passed away two weeks post-transfusion.
    • Anaplasma phagocytophilum DNA was detected in the patient's blood starting seven days after transfusion.
    • Serologic tests for Anaplasma phagocytophilum remained negative until the time of death.

    Implications:

    • This case highlights the potential for transfusion-transmitted anaplasmosis, even with negative serology.
    • It underscores the need for enhanced screening of blood products for Anaplasma phagocytophilum.
    • Improved diagnostic strategies are required to detect infections early in transfusion recipients.
    Keywords:
    Anaplasma phagocytophilumNew YorkUnited Statesanaplasmosisbacterialeukoreductionred blood cell transfusiontransfusion-transmitted infectious disease

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