Related Experiment Video

Updated: Feb 7, 2026

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations
05:04

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations

Published on: February 2, 2024

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Unilateral Phrenic Nerve Palsy in Infants with Congenital Zika Syndrome

Nipunie S Rajapakse, Kevin Ellsworth, Rachael M Liesman

    Emerging Infectious Diseases
    |July 18, 2018
    PubMed

    Since the first identification of neonatal microcephaly cases associated with congenital Zika virus infection in Brazil in 2015, a distinctive constellation of clinical features of congenital Zika syndrome has been described. Fetal brain disruption sequence is hypothesized to underlie the devastating effects of the virus on the central nervous system. However, little is known about the effects of congenital Zika virus infection on the peripheral nervous system. We describe a series of 4 cases of right unilateral diaphragmatic paralysis in infants with congenital Zika syndrome suggesting peripheral nervous system involvement and Zika virus as a unique congenital infectious cause of this finding. All the patients described also had arthrogryposis (including talipes equinovarus) and died from complications related to progressive respiratory failure.

    Keywords:
    Zika viruscongenital Zika syndromefetal diseasesperipheral nervous systemphrenic nervephrenic nerve palsyviruses

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